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Cited 22 times in

TAGLN2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse

DC FieldValueLanguage
dc.contributor.author현영민-
dc.date.accessioned2018-03-26T17:11:16Z-
dc.date.available2018-03-26T17:11:16Z-
dc.date.issued2015-
dc.identifier.issn0021-9525-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/157308-
dc.description.abstractThe formation of an immunological synapse (IS) requires tight regulation of actin dynamics by many actin polymerizing/depolymerizing proteins. However, the significance of actin stabilization at the IS remains largely unknown. In this paper, we identify a novel function of TAGLN2--an actin-binding protein predominantly expressed in T cells--in stabilizing cortical F-actin, thereby maintaining F-actin contents at the IS and acquiring LFA-1 (leukocyte function-associated antigen-1) activation after T cell receptor stimulation. TAGLN2 blocks actin depolymerization and competes with cofilin both in vitro and in vivo. Knockout of TAGLN2 (TAGLN2(-/-)) reduced F-actin content and destabilized F-actin ring formation, resulting in decreased cell adhesion and spreading. TAGLN2(-/-) T cells displayed weakened cytokine production and cytotoxic effector function. These findings reveal a novel function of TAGLN2 in enhancing T cell responses by controlling actin stability at the IS.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherRockefeller University Press-
dc.relation.isPartOfJOURNAL OF CELL BIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHActin Cytoskeleton/metabolism*-
dc.subject.MESHActin Depolymerizing Factors/metabolism-
dc.subject.MESHAnimals-
dc.subject.MESHBinding, Competitive-
dc.subject.MESHCHO Cells-
dc.subject.MESHCricetinae-
dc.subject.MESHCricetulus-
dc.subject.MESHHumans-
dc.subject.MESHImmunological Synapses/metabolism*-
dc.subject.MESHImmunological Synapses/ultrastructure-
dc.subject.MESHJurkat Cells-
dc.subject.MESHLymphocyte Activation-
dc.subject.MESHMice, 129 Strain-
dc.subject.MESHMice, Inbred C57BL-
dc.subject.MESHMice, Knockout-
dc.subject.MESHMicrofilament Proteins/physiology*-
dc.subject.MESHMuscle Proteins/physiology*-
dc.subject.MESHProtein Binding-
dc.subject.MESHProtein Interaction Domains and Motifs-
dc.subject.MESHProtein Stability-
dc.titleTAGLN2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Anatomy-
dc.contributor.googleauthorBo-Ra Na-
dc.contributor.googleauthorHye-Ran Kim-
dc.contributor.googleauthorIndre Piragyte-
dc.contributor.googleauthorHyun-Mee Oh-
dc.contributor.googleauthorMin-Sung Kwon-
dc.contributor.googleauthorUroos Akber-
dc.contributor.googleauthorHyun-Su Lee-
dc.contributor.googleauthorDo-Sim Park-
dc.contributor.googleauthorWoo Keun Son-
dc.contributor.googleauthorZee-Yong Park-
dc.contributor.googleauthorSin-Hyeog Im-
dc.contributor.googleauthorMun-Chual Rho-
dc.contributor.googleauthorYoung-Min Hyun-
dc.contributor.googleauthorMinsoo Kim-
dc.contributor.googleauthorChang-Duk Jun-
dc.identifier.doi10.1083/jcb.201407130-
dc.contributor.localIdA04814-
dc.relation.journalcodeJ01300-
dc.identifier.eissn1540-8140-
dc.identifier.pmid25869671-
dc.contributor.alternativeNameHyun, Young-Min-
dc.contributor.affiliatedAuthorHyun, Young-Min-
dc.citation.volume209-
dc.citation.number1-
dc.citation.startPage143-
dc.citation.endPage162-
dc.identifier.bibliographicCitationJOURNAL OF CELL BIOLOGY, Vol.209(1) : 143-162, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers

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