Amyloid burden, cerebrovascular disease, brain atrophy, and cognition in cognitively impaired patients

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Authors: Byoung Seok Ye ; SangWon Seo ; Geon Ha Kim ; Young Noh ; Hanna Cho ; Cindy W. Yoon ; Hee Jin Kim ; Juhee Chin ; Seun Jeon ; Jong Min Lee ; Joon-Kyung Seong ; Jae Seung Kim ; Jae-Hong Lee ; Yearn Seong Choe ; Kyung Han Lee ; Young H. Sohn ; Michael Ewersl ; Michael Weiner ; Duk L. Na

MeSH: Aged ; Aged, 80 and over ; Amyloid/metabolism* ; Aniline Compounds/pharmacokinetics ; Atrophy/etiology ; Brain/diagnostic imaging ; Brain/pathology* ; Cerebrovascular Disorders/complications* ; Cerebrovascular Disorders/diagnostic imaging ; Cognition Disorders/complications* ; Cognition Disorders/diagnostic imaging ; Cognition Disorders/metabolism ; Cognition Disorders/pathology* ; Female ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Mental Status Schedule ; Middle Aged ; Neuropsychological Tests ; Positron-Emission Tomography ; Retrospective Studies ; Thiazoles/pharmacokinetics

Keywords: Amyloid ; Atrophy ; Cerebrovascular disease ; Cognition ; Cortical thickness ; Hippocampus ; Path analysis ; Pittsburgh compound B

Abstract: BACKGROUND: We investigated the independent effects of Alzheimer's disease (AD) and cerebrovascular disease (CVD) pathologies on brain structural changes and cognition.

METHODS: Amyloid burden (Pittsburgh compound B [PiB] retention ratio), CVD markers (volume of white matter hyperintensities [WMH] and number of lacunae), and structural changes (cortical thickness and hippocampal shape) were measured in 251 cognitively impaired patients. Path analyses were utilized to assess the effects of these markers on cognition.

RESULTS: PiB retention ratio was associated with hippocampal atrophy, which was associated with memory impairment. WMH were associated with frontal thinning, which was associated with executive and memory dysfunctions. PiB retention ratio and lacunae were also associated with memory and executive dysfunction without the mediation of hippocampal or frontal atrophy.

CONCLUSIONS: Our results suggest that the impacts of AD and CVD pathologies on cognition are mediated by specific brain regions.

Full Text: https://www.sciencedirect.com/science/article/pii/S1552526014024194

Appears in Collections:: 1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

Yonsei Authors: Ye, Byoung Seok(예병석) https://orcid.org/0000-0003-0187-8440
Cho, Hanna(조한나) https://orcid.org/0000-0001-5936-1546

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YUHSpace: Amyloid burden, cerebrovascular disease, brain atrophy, and cognition in cognitively impaired patients