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Immunomodulatory Roles of PE/PPE Proteins and Their Implications in Genomic Features of Mycobacterium tuberculosis
DC Field | Value | Language |
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dc.contributor.author | 신성재 | - |
dc.date.accessioned | 2018-03-26T17:07:40Z | - |
dc.date.available | 2018-03-26T17:07:40Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1598-2467 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/157224 | - |
dc.description.abstract | Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), remains a notorious cause of human death worldwide. A deeper understanding of the proline-glutamate (PE) and proline-proline-glutamate (PPE) families, which compromise 10% of the coding regions in the Mtb genome, has uncovered their unique roles in host-pathogen interactions. Further, comparative genomic analysis of different Mtb strains has proposed that Mtb has acquired diverse gene sets that play immunomodulatory roles in host-pathogen interactions. This review delineates the various immunomodulatory roles of PE/PPE antigens and discusses their implications in the development of the improved diagnostic tools and vaccines. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English, Korean | - |
dc.publisher | Seo Heung Pub. Co. | - |
dc.relation.isPartOf | Journal of Bacteriology and Virology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Immunomodulatory Roles of PE/PPE Proteins and Their Implications in Genomic Features of Mycobacterium tuberculosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Microbiology | - |
dc.contributor.googleauthor | Soo Young Choi | - |
dc.contributor.googleauthor | Sung Jae Shin | - |
dc.identifier.doi | 10.4167/jbv.2015.45.3.272 | - |
dc.contributor.localId | A02114 | - |
dc.relation.journalcode | J01255 | - |
dc.identifier.eissn | 2093-0429 | - |
dc.subject.keyword | Tuberculosis | - |
dc.subject.keyword | Mycobacterium tuberculosis | - |
dc.subject.keyword | Immunomodulation | - |
dc.subject.keyword | PE/PPE protein | - |
dc.contributor.alternativeName | Shin, Sung Jae | - |
dc.contributor.affiliatedAuthor | Shin, Sung Jae | - |
dc.citation.volume | 45 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 272 | - |
dc.citation.endPage | 281 | - |
dc.identifier.bibliographicCitation | Journal of Bacteriology and Virology, Vol.45(3) : 272-281, 2015 | - |
dc.identifier.rimsid | 41784 | - |
dc.type.rims | ART | - |
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