Cited 19 times in
Cross‑reactivity between group-5 and -21 mite allergens from Dermatophagoides farinae, Tyrophagus putrescentiae and Blomia tropicalis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김형표 | - |
dc.contributor.author | 용태순 | - |
dc.contributor.author | 이명희 | - |
dc.contributor.author | 정경영 | - |
dc.contributor.author | 정경용 | - |
dc.date.accessioned | 2018-03-26T17:06:35Z | - |
dc.date.available | 2018-03-26T17:06:35Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1791-2997 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/157199 | - |
dc.description.abstract | Group-5 and group-21 allergens, produced by house dust mites and storage mites are 36.6-55.8% identical in their sequences and are recognized by at least 50% of immunoglobulin (Ig)E from the sera of individuals allergic to dust mites. In the present study, recombinant group-5 and ‑21 allergens from three mite species, Dermatophagoides farinae (rDer f 5 and 21), Tyrophagus putrescentiae (rTyr p 5 and 21), and Blomia tropicalis (rBlo t 5 and 21), were purified from Escherichia coli, and the IgE reactivities and cross‑reactivities of these allergen variants were assessed. The IgE binding frequencies of rDer f 5, rDer f 21, rTyr p 5, rTyr p 21, rBlo t and rBlo t 21 proteins were 64.95, 65.98, 30.41, 41.24, 30.93 and 21.65%, respectively. The IgE reactivity of rDer f 5 correlated highly with that of rDer f 21 (r=0.733). rTyr p 5 exhibited the highest level of correlation with rTyr p 21 (r=0.950), while the correlation of rBlo t 5 with rBlo t 21 was the lowest observed (r=0.104). The binding of IgE to rDer f 5 and rDer f 21 was not inhibited by any allergens but themselves. While rDer f 5 inhibited only 60.3% of IgE binding to rBlo t 5, rDer f 21 exhibited a high inhibitory effect against rTyr p 5 (93.01%), rTyr p 21 (92.12%), rBlo t 5 (86.97%) and rBlo t 21 (70.30%), implying cross‑reactivity among mite species. The results of the present study demonstrated that the majority of the IgE reactivity to group-5 and -21 storage mite allergens is due to cross‑reaction. It is therefore imperative to develop an accurate, component‑resolved diagnosis for dust mite allergies. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | D. A. Spandidos | - |
dc.relation.isPartOf | MOLECULAR MEDICINE REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Allergens/chemistry | - |
dc.subject.MESH | Allergens/genetics | - |
dc.subject.MESH | Allergens/immunology* | - |
dc.subject.MESH | Amino Acid Sequence | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antibody Specificity/immunology | - |
dc.subject.MESH | Antigens, Dermatophagoides/chemistry | - |
dc.subject.MESH | Antigens, Dermatophagoides/genetics | - |
dc.subject.MESH | Antigens, Dermatophagoides/immunology* | - |
dc.subject.MESH | Asthma/blood | - |
dc.subject.MESH | Asthma/immunology | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Cross Reactions/immunology* | - |
dc.subject.MESH | Dermatophagoides farinae/genetics | - |
dc.subject.MESH | Dermatophagoides farinae/immunology* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypersensitivity/blood | - |
dc.subject.MESH | Hypersensitivity/immunology | - |
dc.subject.MESH | Immunoglobulin E/blood | - |
dc.subject.MESH | Immunoglobulin E/immunology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Molecular Sequence Data | - |
dc.subject.MESH | Pyroglyphidae/genetics | - |
dc.subject.MESH | Pyroglyphidae/immunology* | - |
dc.subject.MESH | Recombinant Proteins/genetics | - |
dc.subject.MESH | Recombinant Proteins/immunology | - |
dc.subject.MESH | Sequence Alignment | - |
dc.subject.MESH | Young Adult | - |
dc.title | Cross‑reactivity between group-5 and -21 mite allergens from Dermatophagoides farinae, Tyrophagus putrescentiae and Blomia tropicalis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Environmental Medical Biology | - |
dc.contributor.googleauthor | CHUNG‑RYUL KIM | - |
dc.contributor.googleauthor | KYOUNG YONG JEONG | - |
dc.contributor.googleauthor | MYUNG‑HEE YI | - |
dc.contributor.googleauthor | HYOUNG‑PYO KIM | - |
dc.contributor.googleauthor | HO‑JOON SHIN | - |
dc.contributor.googleauthor | TAI‑SOON YONG | - |
dc.identifier.doi | 10.3892/mmr.2015.4093 | - |
dc.contributor.localId | A01163 | - |
dc.contributor.localId | A02424 | - |
dc.contributor.localId | A02761 | - |
dc.contributor.localId | A03572 | - |
dc.relation.journalcode | J02261 | - |
dc.identifier.eissn | 1791-3004 | - |
dc.identifier.pmid | 26238285 | - |
dc.identifier.url | https://www.spandidos-publications.com/mmr/12/4/5467 | - |
dc.contributor.alternativeName | Kim, Hyoung Pyo | - |
dc.contributor.alternativeName | Yong, Tai Soon | - |
dc.contributor.alternativeName | Yi, Myung Hee | - |
dc.contributor.alternativeName | Chung, Kyung Young | - |
dc.contributor.affiliatedAuthor | Kim, Hyoung Pyo | - |
dc.contributor.affiliatedAuthor | Yong, Tai Soon | - |
dc.contributor.affiliatedAuthor | Yi, Myung Hee | - |
dc.contributor.affiliatedAuthor | Jeong, Kyoung Yong | - |
dc.citation.volume | 12 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 5467 | - |
dc.citation.endPage | 5474 | - |
dc.identifier.bibliographicCitation | MOLECULAR MEDICINE REPORTS, Vol.12(4) : 5467-5474, 2015 | - |
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