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Characteristics of Brains in Autism Spectrum Disorder: Structure, Function and Connectivity across the Lifespan

Authors
 Sungji Ha  ;  In-Jung Sohn  ;  Namwook Kim  ;  Hyeon Jeong Sim  ;  Keun-Ah Cheon 
Citation
 EXPERIMENTAL NEUROBIOLOGY, Vol.24(4) : 273-284, 2015 
Journal Title
 EXPERIMENTAL NEUROBIOLOGY 
ISSN
 1226-2560 
Issue Date
2015
Keywords
Autism spectrum disorder (ASD) ; Diffusion tensor image (DTI) ; Functional MRI (fMRI) ; Magnetic resonance image (MRI) ; Neuroimaging
Abstract
Autism spectrum disorder (ASD) is a highly prevalent neurodevelopmental disorder characterized by impaired social communication and restricted and repetitive behaviors (RRBs). Over the past decade, neuroimaging studies have provided considerable insights underlying neurobiological mechanisms of ASD. In this review, we introduce recent findings from brain imaging studies to characterize the brains of ASD across the human lifespan. Results of structural Magnetic Resonance Imaging (MRI) studies dealing with total brain volume, regional brain structure and cortical area are summarized. Using task-based functional MRI (fMRI), many studies have shown dysfunctional activation in critical areas of social communication and RRBs. We also describe several data to show abnormal connectivity in the ASD brains. Finally, we suggest the possible strategies to study ASD brains in the future.
Files in This Item:
T201505806.pdf Download
DOI
10.5607/en.2015.24.4.273
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Nam Wook(김남욱)
Sohn, In-Jung(손인정)
Sim, Hyeon Jeong(심현정)
Cheon, Keun Ah(천근아) ORCID logo https://orcid.org/0000-0001-7113-9286
Ha, Sung Ji(하성지)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/157174
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