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Role of Radiotherapy in the Multimodal Treatment of Ewing Sarcoma Family Tumors

 Yunseon Choi  ;  Do Hoon Lim  ;  Soo Hyun Lee  ;  Chuhl Joo Lyu  ;  Jung Ho Im  ;  Yun-Han Lee  ;  Chang-Ok Suh 
 CANCER RESEARCH AND TREATMENT, Vol.47(4) : 904-912, 2015 
Journal Title
Issue Date
Adolescent ; Adult ; Antineoplastic Agents/therapeutic use* ; Bone Neoplasms/drug therapy* ; Bone Neoplasms/radiotherapy* ; Child ; Child, Preschool ; Combined Modality Therapy/methods* ; Female ; Humans ; Infant ; Male ; Middle Aged ; Neoadjuvant Therapy ; Neoplasm Recurrence, Local ; Retrospective Studies ; Sarcoma, Ewing/drug therapy* ; Sarcoma, Ewing/radiotherapy* ; Treatment Outcome ; Young Adult
Ewing sarcoma ; Radiotherapy ; Surgery ; Tumor burden
PURPOSE: The aim of this study was to evaluate the role of radiotherapy (RT) in the management of Ewing sarcoma family tumors (ESFT). MATERIALS AND METHODS: Retrospective analysiswas performed on 91 patientswith localized ESFT treated from 1988 to 2012. Primary tumor size was ≥ 8 cm in 33 patients. Surgery, RT, and combined surgery with RT were applied in 37, 15, and 33 patients, respectively. RESULTS: Median follow-up was 43.8 months. Forty-three patients (47.3%) showed recurrence or progressive disease. Twelve patients (13.2%) showed local failure after initial treatment. Thirty-nine patients (42.9%) experienced distant metastases. The 5-year overall survival (OS), progression-free survival, and local control (LC) were 60.5%, 58.2%, and 85.1%, respectively. According to treatment, 5-year LCwas 64.8% with RT and 90.2% with combined surgery and RT (p=0.052). Prognostic factors for OS were tumor size (≥ 8 cm, p < 0.001) and surgical resection (p < 0.001). In large tumors (≥ 8 cm), combined surgery and RT produced better LC compared to RT (p=0.033). However, in smaller tumors (< 8 cm), RT without surgery resulted in a similar LC rate as RT with surgery (p=0.374). CONCLUSION: RT used for patients with unfavorable risk factors resulted in worse outcome than for patientswho received surgery. Smallertumors could be controlled locallywith chemotherapy and RT. For large tumors, combined surgery and RT is needed. Proper selection of local treatment modality, RT, surgery, or both is crucial in the management of ESFT.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Suh, Chang Ok(서창옥)
Lyu, Chuhl Joo(유철주) ORCID logo https://orcid.org/0000-0001-7124-7818
Lee, Soo Hyeon(이수현)
Lee, Yun Han(이윤한)
Im, Jung Ho(임정호)
Choi, Yun Seon(최윤선)
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