Cited 37 times in
The role of deubiquitinating enzymes in spermatogenesis
DC Field | Value | Language |
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dc.contributor.author | 이준원 | - |
dc.date.accessioned | 2018-03-26T17:05:28Z | - |
dc.date.available | 2018-03-26T17:05:28Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1420-682X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/157170 | - |
dc.description.abstract | Spermatogenesis is a complex process through which spermatogonial stem cells undergo mitosis, meiosis, and cell differentiation to generate mature spermatozoa. During this process, male germ cells experience several translational modifications. One of the major post-translational modifications in eukaryotes is the ubiquitination of proteins, which targets proteins for degradation; this enables control of the expression of enzymes and structural proteins during spermatogenesis. It has become apparent that ubiquitination plays a key role in regulating every stage of spermatogenesis starting from gonocytes to differentiated spermatids. It is understood that, where there is ubiquitination, deubiquitination by deubiquitinating enzymes (DUBs) also exists to counterbalance the ubiquitination process in a reversible manner. Normal spermatogenesis is dependent on the balanced actions of ubiquitination and deubiquitination. This review highlights the current knowledge of the role of DUBs and their essential regulatory contribution to spermatogenesis, especially during progression into meiotic phase, acrosome biogenesis, quality sperm production, and apoptosis of germ cells. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer | - |
dc.relation.isPartOf | CELLULAR AND MOLECULAR LIFE SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Differentiation | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Spermatogenesis/genetics | - |
dc.subject.MESH | Spermatogenesis/physiology* | - |
dc.subject.MESH | Ubiquitin/metabolism | - |
dc.subject.MESH | Ubiquitin-Specific Proteases/genetics | - |
dc.subject.MESH | Ubiquitin-Specific Proteases/metabolism | - |
dc.subject.MESH | Ubiquitin-Specific Proteases/physiology* | - |
dc.subject.MESH | Ubiquitination | - |
dc.title | The role of deubiquitinating enzymes in spermatogenesis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Ophthalmology | - |
dc.contributor.googleauthor | Bharathi Suresh | - |
dc.contributor.googleauthor | Junwon Lee | - |
dc.contributor.googleauthor | Seok-Ho Hong | - |
dc.contributor.googleauthor | Kye-Seong Kim | - |
dc.contributor.googleauthor | Suresh Ramakrishna | - |
dc.identifier.doi | 10.1007/s00018-015-2030-z | - |
dc.contributor.localId | A03179 | - |
dc.relation.journalcode | J00496 | - |
dc.identifier.eissn | 1420-9071 | - |
dc.identifier.pmid | 26350476 | - |
dc.identifier.url | https://link.springer.com/article/10.1007/s00018-015-2030-z | - |
dc.subject.keyword | Acrosome | - |
dc.subject.keyword | Gonocytes | - |
dc.subject.keyword | Male infertility | - |
dc.subject.keyword | Nucleosome | - |
dc.subject.keyword | Proteasome | - |
dc.subject.keyword | Protein degradation | - |
dc.subject.keyword | Spermiogenesis | - |
dc.subject.keyword | Ubiquitin | - |
dc.contributor.alternativeName | Lee, Jun Won | - |
dc.contributor.affiliatedAuthor | Lee, Jun Won | - |
dc.citation.volume | 72 | - |
dc.citation.number | 24 | - |
dc.citation.startPage | 4711 | - |
dc.citation.endPage | 4720 | - |
dc.identifier.bibliographicCitation | CELLULAR AND MOLECULAR LIFE SCIENCES, Vol.72(24) : 4711-4720, 2015 | - |
dc.identifier.rimsid | 41731 | - |
dc.type.rims | ART | - |
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