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Integrated Proteomic and Genomic Analysis of Gastric Cancer Patient Tissues

Authors
 Julia Fangfei Yan  ;  Hoguen Kim  ;  Seul-Ki Jeong  ;  Hyoung-Joo Lee  ;  Manveen K. Sethi  ;  Ling Y. Lee  ;  Ronald C. Beavis  ;  Hogune Im  ;  Michael P. Snyder  ;  Matan Hofree  ;  Trey Ideker  ;  Shiaw-lin Wu  ;  Young-Ki Paik  ;  Susan Fanayan  ;  William S. Hancock 
Citation
 JOURNAL OF PROTEOME RESEARCH, Vol.14(12) : 4995-5006, 2015 
Journal Title
 JOURNAL OF PROTEOME RESEARCH 
ISSN
 1535-3893 
Issue Date
2015
MeSH
Case-Control Studies ; Cell Line, Tumor ; Gene Expression Profiling ; Humans ; Immunohistochemistry ; In Situ Hybridization, Fluorescence ; Receptor, ErbB-2/metabolism* ; Stomach Neoplasms/genetics* ; Stomach Neoplasms/metabolism*
Keywords
Chromosome-centric Human Proteome Project ; EGFR ; ERBB2 ; GRB2 ; RNA-Seq ; gastric cancer patient tissues
Abstract
V-erb-b2 erythroblastic leukemia viral oncogene homologue 2, known as ERBB2, is an important oncogene in the development of certain cancers. It can form a heterodimer with other epidermal growth factor receptor family members and activate kinase-mediated downstream signaling pathways. ERBB2 gene is located on chromosome 17 and is amplified in a subset of cancers, such as breast, gastric, and colon cancer. Of particular interest to the Chromosome-Centric Human Proteome Project (C-HPP) initiative is the amplification mechanism that typically results in overexpression of a set of genes adjacent to ERBB2, which provides evidence of a linkage between gene location and expression. In this report we studied patient samples from ERBB2-positive together with adjacent control nontumor tissues. In addition, non-ERBB2-expressing patient samples were selected as comparison to study the effect of expression of this oncogene. We detected 196 proteins in ERBB2-positive patient tumor samples that had minimal overlap (29 proteins) with the non-ERBB2 tumor samples. Interaction and pathway analysis identified extracellular signal regulated kinase (ERK) cascade and actin polymerization and actinmyosin assembly contraction as pathways of importance in ERBB2+ and ERBB2- gastric cancer samples, respectively. The raw data files are deposited at ProteomeXchange (identifier: PXD002674) as well as GPMDB.
Files in This Item:
T201505671.pdf Download
DOI
10.1021/acs.jproteome.5b00827
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hogeun(김호근)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/157156
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