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The Immunogenicity and Safety of the Live-attenuated SA 14-14-2 Japanese Encephalitis Vaccine Given with a Two-dose Primary Schedule in Children

Authors
 Hyo Jin Kwon  ;  Soo Young Lee  ;  Ki Hwan Kim  ;  Dong Soo Kim  ;  Sung Ho Cha  ;  Dae Sun Jo  ;  Jin Han Kang 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.30(5) : 612-616, 2015 
Journal Title
 JOURNAL OF KOREAN MEDICAL SCIENCE 
ISSN
 1011-8934 
Issue Date
2015
MeSH
Antibodies, Neutralizing/analysis ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/analysis ; Antibodies, Viral/immunology ; Antibody Formation ; Child, Preschool ; Cohort Studies ; Encephalitis, Japanese/prevention & control* ; Female ; Humans ; Infant ; Japanese Encephalitis Vaccines/immunology* ; Male ; Prospective Studies ; Vaccination ; Vaccines, Attenuated/immunology*
Keywords
Children ; Clinical Trial ; Immunogenicity ; Live Attenuated Japanese Encephalitis Vaccine ; Safety
Abstract
Effective and tolerable vaccination is an essential strategy to prevent Japanese encephalitis (JE) in endemic areas. Although the live attenuated SA 14-14-2 JE vaccine (LAJEV) has been widely used since its introduction, the systemic data of LAJEV was very rarely available in Korea. We conducted the open-label, prospective cohort study to assess the immunogenicity and safety of this vaccine. Ninety subjects were enrolled, and LAJEV in a 2-dose primary series was given with a 12-month interval. Neutralizing antibody titers were measured before and after each vaccination, and active monitoring for adverse events was performed. After the first dose, 91.1% of subjects had seroprotection with a geometric mean titer (GMT) of 40.9. Seroprotection rate after the second dose was 97%, and GMT showed an increase of 6.5-fold. Most adverse events following immunization were self-limited, and no serious adverse events were reported until 42 days after each dose. The 2-dose administration of LAJEV in the primary immunization schedule appeared to be highly immunogenic and safe.
Files in This Item:
T201505644.pdf Download
DOI
10.3346/jkms.2015.30.5.612
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ki Hwan(김기환)
Kim, Dong Soo(김동수)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/157151
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