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A colorectal cancer prediction model using traditional and genetic risk scores in Koreans

Authors
 Keum Ji Jung  ;  Daeyoun Won  ;  Christina Jeon  ;  Soriul Kim  ;  Tae Il Kim  ;  Sun Ha Jee  ;  Terri H Beaty 
Citation
 BMC GENETICS, Vol.16 : 49, 2015 
Journal Title
 BMC GENETICS 
Issue Date
2015
MeSH
Adult ; Asian Continental Ancestry Group/genetics* ; Cohort Studies ; Colorectal Neoplasms/epidemiology* ; Colorectal Neoplasms/genetics* ; Female ; Genetic Predisposition to Disease* ; Genome-Wide Association Study ; Humans ; Male ; Middle Aged ; Models, Theoretical* ; Polymorphism, Single Nucleotide ; Proportional Hazards Models ; ROC Curve ; Registries ; Republic of Korea/epidemiology ; Risk* ; Risk Factors
Keywords
Single nucleotide polymorphisms ; Gene-traditional risk score ; Colorectal cancer
Abstract
BACKGROUND: Genome-wide association studies have identified numerous single nucleotide polymorphisms (SNPs) as associated with colorectal cancer (CRC) risk in populations of European descent. However, their utility for predicting risk to CRC in Asians remains unknown. A case-cohort study (random sub-cohort N=1,685) from the Korean Cancer Prevention Study-II (KCPS-II) (N=145,842) was used. Twenty-three SNPs identified in previous 47 studies were genotyped on the KCPS-II sub-cohort members. A genetic risk score (GRS) was calculated by summing the number of risk alleles over all SNPs. Prediction models with or without GRS were evaluated in terms of the area under the receiver operating characteristic curve (AUROC) and the continuous net reclassification index (NRI). RESULTS: Seven of 23 SNPs showed significant association with CRC and rectal cancer in Koreans, but not with colon cancer alone. AUROCs (95% CI) for traditional risk score (TRS) alone and TRS plus GRS were 0.73 (0.69-0.78) and 0.74 (0.70-0.78) for CRC, and 0.71 (0.65-0.77) and 0.74 (0.68-0.79) for rectal cancer, respectively. The NRI (95% CI) for a prediction model with GRS compared to the model with TRS alone was 0.17 (-0.05-0.37) for CRC and 0.41 (0.10-0.68) for rectal cancer alone. CONCLUSION: Our results indicate genetic variants may be useful for predicting risk to CRC in the Koreans, especially risk for rectal cancer alone. Moreover, this study suggests effective prediction models for colon and rectal cancer should be developed separately.
Files in This Item:
T201505522.pdf Download
DOI
10.1186/s12863-015-0207-y
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Kim, Tae Il(김태일) ORCID logo https://orcid.org/0000-0003-4807-890X
Jung, Keum Ji(정금지) ORCID logo https://orcid.org/0000-0003-4993-0666
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/157117
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