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Increased Expression of Circulating Cancer Stem Cell Markers During the Perioperative Period Predicts Early Recurrence After Curative Resection of Hepatocellular Carcinoma

DC Field Value Language
dc.contributor.author김광일-
dc.contributor.author나득채-
dc.contributor.author노윤호-
dc.contributor.author박영년-
dc.contributor.author유정은-
dc.contributor.author최기홍-
dc.contributor.author최진섭-
dc.contributor.author한대훈-
dc.date.accessioned2018-03-26T17:00:44Z-
dc.date.available2018-03-26T17:00:44Z-
dc.date.issued2015-
dc.identifier.issn1068-9265-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/157072-
dc.description.abstractBACKGROUND: This study was designed to investigate the correlation between postoperative recurrence of hepatocellular carcinoma (HCC) and perioperative expression and dynamic changes in cancer stem cell (CSC) markers in tumors and peripheral blood. METHODS: In HCC patients who underwent curative resection (n = 64) or liver transplantation (LT) (n = 17), mRNA levels for K19, EpCAM, and CD44 in peripheral blood and HCC tissues before and after operation were examined using real-time RT-PCR. Postoperative recurrence was analyzed in patients who underwent resection. Study participants were divided into high and low ratio groups, according to the ratio of postoperative to preoperative mRNA levels for each marker. RESULTS: K19 and CD44 mRNA levels in HCC tissues were higher in patients with recurrence than those without recurrence (p < 0.05 for all). Preoperative peripheral levels of K19 and EpCAM mRNA were higher in LT patients than in resection patients, and they were also significantly higher in cirrhotic patients of Child-Pugh Class B or C than those of Child-Pugh Class A (p < 0.05 for all). A high ratio of K19 mRNA was associated with lower relapse-free rate. Additionally, a high ratio for both K19 and CD44 mRNA was an independent poor prognostic factor for relapse-free survival (hazard ratio = 3.382, p = 0.016). CONCLUSIONS: Preoperative peripheral levels of K19 and EpCAM mRNA were influenced by background liver status and HCC. Additionally, the ratio of postoperative to preoperative mRNA levels for CSC markers, especially K19 and CD44, was shown to be important to predict HCC recurrence.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringer-
dc.relation.isPartOfANNALS OF SURGICAL ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBiomarkers, Tumor/blood*-
dc.subject.MESHCarcinoma, Hepatocellular/blood*-
dc.subject.MESHCarcinoma, Hepatocellular/pathology-
dc.subject.MESHCarcinoma, Hepatocellular/surgery-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHepatectomy-
dc.subject.MESHHumans-
dc.subject.MESHImmunoenzyme Techniques-
dc.subject.MESHLiver Neoplasms/blood*-
dc.subject.MESHLiver Neoplasms/pathology-
dc.subject.MESHLiver Neoplasms/surgery-
dc.subject.MESHLiver Transplantation-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Recurrence, Local/blood*-
dc.subject.MESHNeoplasm Recurrence, Local/pathology-
dc.subject.MESHNeoplasm Recurrence, Local/surgery-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHNeoplastic Cells, Circulating/pathology*-
dc.subject.MESHNeoplastic Stem Cells/metabolism-
dc.subject.MESHNeoplastic Stem Cells/pathology*-
dc.subject.MESHPerioperative Period-
dc.subject.MESHPrognosis-
dc.subject.MESHProspective Studies-
dc.subject.MESHRNA, Messenger/genetics-
dc.subject.MESHReal-Time Polymerase Chain Reaction-
dc.subject.MESHReverse Transcriptase Polymerase Chain Reaction-
dc.subject.MESHSurvival Rate-
dc.titleIncreased Expression of Circulating Cancer Stem Cell Markers During the Perioperative Period Predicts Early Recurrence After Curative Resection of Hepatocellular Carcinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentYonsei Biomedical Research Center-
dc.contributor.googleauthorGi Hong Choi-
dc.contributor.googleauthorGwang Il Kim-
dc.contributor.googleauthorJeong Eun Yoo-
dc.contributor.googleauthorDeuk Chae Na-
dc.contributor.googleauthorDai Hoon Han-
dc.contributor.googleauthorYun Ho Roh-
dc.contributor.googleauthorYoung Nyun Park-
dc.contributor.googleauthorJin Sub Choi-
dc.identifier.doi10.1245/s10434-015-4480-9-
dc.contributor.localIdA00316-
dc.contributor.localIdA01231-
dc.contributor.localIdA01287-
dc.contributor.localIdA01563-
dc.contributor.localIdA02504-
dc.contributor.localIdA04046-
dc.contributor.localIdA04199-
dc.contributor.localIdA04273-
dc.relation.journalcodeJ00179-
dc.identifier.eissn1534-4681-
dc.identifier.pmid25791790-
dc.identifier.urlhttps://link.springer.com/article/10.1245/s10434-015-4480-9-
dc.subject.keywordPostoperative Recurrence-
dc.subject.keywordCD44 mRNA-
dc.subject.keywordCancer Stem Cell Marker-
dc.subject.keywordPugh Class-
dc.subject.keywordEpCAM mRNA-
dc.contributor.alternativeNameKim, Gwang Il-
dc.contributor.alternativeNameNa, Deuk Chae-
dc.contributor.alternativeNameRoh, Yun Ho-
dc.contributor.alternativeNamePark, Young Nyun-
dc.contributor.alternativeNameYoo, Jeong Eun-
dc.contributor.alternativeNameChoi, Gi Hong-
dc.contributor.alternativeNameChoi, Jin Sub-
dc.contributor.alternativeNameHan, Dai Hoon-
dc.contributor.affiliatedAuthorKim, Gwang Il-
dc.contributor.affiliatedAuthorNa, Deuk Chae-
dc.contributor.affiliatedAuthorRoh, Yun Ho-
dc.contributor.affiliatedAuthorPark, Young Nyun-
dc.contributor.affiliatedAuthorYoo, Jeong Eun-
dc.contributor.affiliatedAuthorChoi, Gi Hong-
dc.contributor.affiliatedAuthorChoi, Jin Sub-
dc.contributor.affiliatedAuthorHan, Dai Hoon-
dc.citation.volume22-
dc.citation.numberSuppl 3-
dc.citation.startPageS1444-
dc.citation.endPageS1452-
dc.identifier.bibliographicCitationANNALS OF SURGICAL ONCOLOGY, Vol.22(Suppl 3) : S1444-S1452, 2015-
dc.identifier.rimsid41380-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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