Cited 0 times in
Root resorption in streptozotocin-induced diabetic rats with ligature-induced periodontitis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박은정 | - |
dc.contributor.author | 유윤정 | - |
dc.contributor.author | 이동은 | - |
dc.contributor.author | 차정헌 | - |
dc.date.accessioned | 2018-03-26T16:57:43Z | - |
dc.date.available | 2018-03-26T16:57:43Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1226-7155 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/157012 | - |
dc.description.abstract | To determine the effect of diabetes on root resorption in periodontitis, we investigated odontoclast formation and root resorption in diabetic rats with periodontitis. Odontoclast formation was observed in three groups of F344 rats: Controls (C) were normal rats without diabetes or periodontitis; the periodontitis (P) group had mandibular first molars to be ligatured; the periodontitis with diabetes (PD) group was intravenously administered streptozotocin (50 mg/kg) to induce diabetes and had mandibular first molars to be ligatured. On days 3, 10, and 20 after ligature, tumor necrosis factor (TNF)-α and receptor activator of nuclear factor-κB ligand (RANKL) expression, odontoclast formation, and root resorption areas were evaluated by immunohistochemistry, tartrate-resistant acid phosphatase staining, and hematoxylin and eosin staining, respectively. The PD group showed frequent urination, weight loss, and hyperglycemia. Numbers of TNF-α- and RANKL-positive cells were higher in the P and PD groups than in the C group. It was more prevalent in PD group on day 3. Odontoclast formation was greater in the P and PD groups than in the C group on days 3 and 10, then decreased to same level as the C group by day 20. Root resorption in the PD and P groups showed increases on days 3 and 10, respectively, compared to the C group. These results suggest that diabetes may transiently increase root resorption on day 3 with high expression of TNF-α and RANKL after periodontitis induction. This study could aid the understanding of root resorption in diabetic patients with periodontitis. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Harn Rim Won Printing Co. | - |
dc.relation.isPartOf | International Journal of Oral Biology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Root resorption in streptozotocin-induced diabetic rats with ligature-induced periodontitis | - |
dc.type | Article | - |
dc.contributor.college | Research Institutes | - |
dc.contributor.department | Oral Cancer Research Institute | - |
dc.contributor.googleauthor | Ji-Hye Kim | - |
dc.contributor.googleauthor | Dong-Eun Lee | - |
dc.contributor.googleauthor | Jung-Chul Park | - |
dc.contributor.googleauthor | Yoon Jae Kim | - |
dc.contributor.googleauthor | Jeong-Heon Cha | - |
dc.contributor.googleauthor | Eun-Jung Bak | - |
dc.contributor.googleauthor | Yun-Jung Yoo | - |
dc.identifier.doi | 10.11620/IJOB.2015.40.3.111 | - |
dc.contributor.localId | A01614 | - |
dc.contributor.localId | A02490 | - |
dc.contributor.localId | A02730 | - |
dc.contributor.localId | A04007 | - |
dc.relation.journalcode | J01144 | - |
dc.subject.keyword | Diabetes Mellitus | - |
dc.subject.keyword | Odontoclasts | - |
dc.subject.keyword | Periodontitis | - |
dc.subject.keyword | Root Resorption | - |
dc.contributor.alternativeName | Bak, Eun-Jung | - |
dc.contributor.alternativeName | Yoo, Yun Jung | - |
dc.contributor.alternativeName | Lee, Dong Eun | - |
dc.contributor.alternativeName | Cha, Jung Heon | - |
dc.contributor.affiliatedAuthor | Bak, Eun-Jung | - |
dc.contributor.affiliatedAuthor | Yoo, Yun Jung | - |
dc.contributor.affiliatedAuthor | Lee, Dong Eun | - |
dc.contributor.affiliatedAuthor | Cha, Jung Heon | - |
dc.citation.volume | 40 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 111 | - |
dc.citation.endPage | 116 | - |
dc.identifier.bibliographicCitation | International Journal of Oral Biology, Vol.40(3) : 111-116, 2015 | - |
dc.identifier.rimsid | 41321 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.