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Identification of human papillomavirus status specific biomarker in head and neck cancer

 Ki-Yeol Kim  ;  Xianglan Zhang  ;  In-Ho Cha 
 Head & Neck, Vol.37(9) : 1310-1318, 2015 
Journal Title
 Head & Neck 
Issue Date
Adult ; Aged ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/physiopathology ; Carcinoma, Squamous Cell/virology* ; DNA, Viral/genetics* ; Databases, Factual ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Viral ; Head and Neck Neoplasms/genetics ; Head and Neck Neoplasms/physiopathology ; Head and Neck Neoplasms/virology* ; Humans ; Male ; Microarray Analysis ; Middle Aged ; Papillomaviridae/genetics* ; Papillomaviridae/isolation & purification ; Papillomavirus Infections/diagnosis ; Papillomavirus Infections/genetics* ; Prognosis ; Reproducibility of Results ; Risk Assessment ; Sampling Studies ; Sensitivity and Specificity ; Statistics, Nonparametric
head and neck cancer ; human papillomavirus ; human papillomavirus (HPV) status-specific gene set ; microarray data ; prognosis
BACKGROUND: In an attempt to improve the prognosis of patients with head and neck cancer, it could be necessary to identify biomarkers in homogeneous subgroups of patients with head and neck cancer. METHODS: We explored the necessity of human papillomavirus (HPV) status-specific biomarkers in patients with head and neck cancer and identified an HPV status-specific gene set. The identified gene set was validated with the external microarray datasets. For this purpose, we used 4 microarray datasets obtained from a public database. One dataset was used for identifying the HPV status specific gene set, and the other datasets were used for validation. RESULTS: The identified gene set for distinguishing head and neck cancer from head and neck normal, did not accurately discriminate the HPV specific patients with head and neck cancer from the head and neck normal group. Also, it was demonstrated that some HPV-positive (HPV+) head and neck cancer-specific genes may not be significant in HPV-negative (HPV-) head and neck cancer patients. The identified HPV specific gene sets showed good performance in validation datasets. The HPV+ head and neck cancer-specific gene set included various metabolism-related pathways, and the HPV- head and neck cancer-specific gene set included several pathways; fibroblast, collagen degradation, actin-binding, and actin cytoskeleton. CONCLUSION: The identification of HPV status-specific significant gene set was necessary. It is expected that HPV status-specific biomarkers can be helpful in deciding therapeutic methods for patients with head and neck cancer, after biological validation and large prospective trials.
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Appears in Collections:
5. Research Institutes (연구소) > Oral Cancer Research Institute (구강종양연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ki Yeol(김기열) ORCID logo https://orcid.org/0000-0001-5357-1067
Zhang, Xiang Lan(장향란)
Cha, In Ho(차인호) ORCID logo https://orcid.org/0000-0001-8259-2190
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