107 216

Cited 10 times in

Depression as a risk factor for overall and hormone-related cancer: the Korean cancer prevention study

Authors
 Hyoung Yoon Chang  ;  Katherine M. Keyes  ;  Yejin Mok  ;  Keum Ji Jung  ;  Yee-Jin Shin  ;  Sun Ha Jee 
Citation
 JOURNAL OF AFFECTIVE DISORDERS, Vol.173 : 1-8, 2015 
Journal Title
 JOURNAL OF AFFECTIVE DISORDERS 
ISSN
 0165-0327 
Issue Date
2015
MeSH
Adult ; Asian Continental Ancestry Group/psychology ; Breast Neoplasms/epidemiology* ; Cohort Studies ; Depression/epidemiology* ; Depressive Disorder, Major/epidemiology* ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Prostatic Neoplasms/epidemiology* ; Registries ; Republic of Korea/epidemiology ; Risk Factors ; Uterine Cervical Neoplasms/epidemiology*
Keywords
Cancer ; Cervical cancer ; Depression ; Prostate cancer ; Republic of Korea
Abstract
Depression has been hypothesized to be a risk factor of cancer, especially hormone-related cancers. However, few studies have been conducted with large enough sample size and sufficient follow-up period to rigorously estimate these associations. We aim to examine the relationship between depression and risk of registry-documented overall and hormone-related cancers. In this 19 year prospective cohort study of general population, 601,775 Koreans aged 30-64 years had a biennial medical evaluation by the National Health Insurance Service in either 1992 or 1994. Major and minor depression was ascertained by a 9-item depression questionnaire. At baseline, major depression was identified in 7.4% and 10.2% and minor depression in 19.3% and 21.4% in men and women, respectively. During the follow-up, 49,744 cancers were identified in men and 7860 in women. Prostate cancer in men was positively related to minor depression (HR 1.13, 95% CI 1.05, 1.23), and cervical cancer in women was inversely related to major depression (HR 0.90, 95% CI 0.83, 0.98) after adjusting for potential confounders. Regarding overall cancer, major depression was positively related to overall cancer in men (HR 1.04, 95% CI 1.00, 1.08) and inversely related in women (HR 0.90, 95% CI 0.83, 0.98). There was no association between breast cancer and depression. Different direction and magnitude of association among gender and cancer subtypes suggest different psycho-behavioral and biological pathways in which depression may affect later cancer development. Further studies on the association of depression and cancer and the underlying mechanisms should be conducted on specific cancer subtypes.
Files in This Item:
T201505022.pdf Download
DOI
10.1016/j.jad.2014.10.064
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Mok, Ye Jin(목예진)
Shin, Yee Jin(신의진) ORCID logo https://orcid.org/0000-0001-8573-4342
Jung, Keum Ji(정금지) ORCID logo https://orcid.org/0000-0003-4993-0666
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/157001
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links