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Effects of education on aging-related cortical thinning among cognitively normal individuals

Authors
 Jun Pyo Kim  ;  Sang Won Seo  ;  Hee Young Shin  ;  Byoung Seok Ye  ;  Jin-Ju Yang  ;  Changsoo Kim  ;  Mira Kang  ;  Seun Jeon  ;  Hee Jin Kim  ;  Hanna Cho  ;  Jung-Hyun Kim  ;  Jong-Min Lee  ;  Sung Tae Kim  ;  Duk L. Na  ;  Eliseo Guallar 
Citation
 NEUROLOGY, Vol.85(9) : 806-812, 2015 
Journal Title
 NEUROLOGY 
ISSN
 0028-3878 
Issue Date
2015
MeSH
Aged ; Aged, 80 and over ; Aging/pathology* ; Aging/psychology ; Cerebral Cortex/pathology* ; Educational Status* ; Female ; Humans ; Image Processing, Computer-Assisted ; Imaging, Three-Dimensional ; Linear Models ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Organ Size
Abstract
OBJECTIVES: We aimed to investigate the relationship between education and cortical thickness in cognitively normal individuals to determine whether education attenuated the association of advanced aging and cortical thinning. METHODS: A total of 1,959 participants, in whom education levels were available, were included in the final analysis. Cortical thickness was measured on high-resolution MRIs using a surface-based method. Multiple linear regression analysis was performed for education level and cortical thickness, after controlling for possible confounders. RESULTS: High levels of education were correlated with increased mean cortical thickness throughout the entire cortex (p = 0.003). This association persisted after controlling for vascular risk factors. Statistical maps of cortical thickness showed that the high levels of education were correlated with increased cortical thickness in the bilateral premotor areas, anterior cingulate cortices, perisylvian areas, right superior parietal lobule, left lingual gyrus, and occipital pole. There were also interactive effects of age and education on the mean cortical thickness (p = 0.019). CONCLUSIONS: Our findings suggest the protective effect of education on cortical thinning in cognitively normal older individuals, regardless of vascular risk factors. This effect was found only in the older participants, suggesting that the protective effects of education on cortical thickness might be achieved by increased resistance to structural loss from aging rather than by simply providing a fixed advantage in the brain.
Full Text
http://n.neurology.org/content/85/9/806
DOI
10.1212/WNL.0000000000001884
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Soo(김창수) ORCID logo https://orcid.org/0000-0002-5940-5649
Ye, Byoung Seok(예병석) ORCID logo https://orcid.org/0000-0003-0187-8440
Cho, Hanna(조한나) ORCID logo https://orcid.org/0000-0001-5936-1546
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/156958
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