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Reconstitution of lymphocyte subpopulations after hematopoietic stem cell transplantation: comparison of hematologic malignancies and donor types in event-free patients

Authors
 Borae G. Park  ;  Chan-Jeoung Park  ;  Seongsoo Jang  ;  Hyun-Sook Chi  ;  Dae-Young Kim  ;  Jung-Hee Lee  ;  Je-Hwan Lee  ;  Kyoo-Hyung Lee 
Citation
 LEUKEMIA RESEARCH, Vol.39(12) : 1334-1341, 2015 
Journal Title
 LEUKEMIA RESEARCH 
ISSN
 0145-2126 
Issue Date
2015
MeSH
Adolescent ; Adult ; Aged ; Allografts ; Disease-Free Survival ; Female ; Flow Cytometry ; Follow-Up Studies ; Graft Survival ; Hematopoietic Stem Cell Transplantation* ; Histocompatibility ; Humans ; Immunophenotyping ; Immunosuppressive Agents/therapeutic use ; Leukemia, Myeloid, Acute/therapy ; Living Donors ; Lymphocyte Count ; Lymphocyte Subsets* ; Male ; Middle Aged ; Myelodysplastic Syndromes/therapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy ; Prospective Studies ; Siblings ; Transplantation Conditioning ; Young Adult
Keywords
Haploidentical stem cell transplantation ; Hematopoietic stem cell transplantation ; Immune reconstitution ; Lymphocyte subpopulation
Abstract
The reconstitution of different immunocyte subsets after hematopoietic stem cell transplantation (HSCT), follows different timelines. We prospectively investigated changes in lymphocyte subsets after HSCT and their associations with primary diagnosis, conditioning regimen, and HSCT type in event-free patients. A total of 95 patients (48 with acute myeloid leukemia, 22 with acute lymphoid leukemia, and 25 with myelodysplastic syndrome) who underwent allogeneic HSCT (34 sibling matched, 37 unrelated matched, and 24 haploidentical HSCT) but did not experience any events such as relapse or death were enrolled in this study. Lymphocyte subpopulations (T cells, helper/inducer T cells, cytotoxic/suppressor T cells, memory T cells, regulatory T cells, natural killer (NK) cells, NK-T cells, and B cells) were quantified by flow cytometry of peripheral blood from recipients 7 days before and 1, 2, 3, 6, and 12 months after HSCT. Leukocyte counts recovered within 1 month after HSCT. However, the number of T and B lymphocytes recovered at 2 months after HSCT. NK cell counts recovered shortly after haploidentical HSCT. However, T lymphocytes and their subpopulations showed delayed recovery after haploidentical HSCT. Lymphocyte subsets showed different sequential patterns according to HSCT type but no differences were seen according to primary diagnosis or conditioning regimen.
Full Text
http://www.sciencedirect.com/science/article/pii/S0145212615303817
DOI
10.1016/j.leukres.2015.09.010
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Park, Borae G(박금보래)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/156956
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