Cited 46 times in
Regeneration of Full-Thickness Rotator Cuff Tendon Tear After Ultrasound-Guided Injection With Umbilical Cord Blood-Derived Mesenchymal Stem Cells in a Rabbit Model
DC Field | Value | Language |
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dc.contributor.author | 이상철 | - |
dc.date.accessioned | 2018-03-26T16:53:50Z | - |
dc.date.available | 2018-03-26T16:53:50Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1066-5099 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/156933 | - |
dc.description.abstract | Rotator cuff tendon tear is one of the most common causes of chronic shoulder pain and disability. In this study, we investigated the therapeutic effects of ultrasound-guided human umbilical cord blood (UCB)-derived mesenchymal stem cell (MSC) injection to regenerate a full-thickness subscapularis tendon tear in a rabbit model by evaluating the gross morphology and histology of the injected tendon and motion analysis of the rabbit's activity. At 4 weeks after ultrasound-guided UCB-derived MSC injection, 7 of the 10 full-thickness subscapularis tendon tears were only partial-thickness tears, and 3 remained full-thickness tendon tears. The tendon tear size and walking capacity at 4 weeks after UCB-derived MSC injection under ultrasound guidance were significantly improved compared with the same parameters immediately after tendon tear. UCB-derived MSC injection under ultrasound guidance without surgical repair or bioscaffold resulted in the partial healing of full-thickness rotator cuff tendon tears in a rabbit model. Histology revealed that UCB-derived MSCs induced regeneration of rotator cuff tendon tear and that the regenerated tissue was predominantly composed of type I collagens. In this study, ultrasound-guided injection of human UCB-derived MSCs contributed to regeneration of the full-thickness rotator cuff tendon tear without surgical repair. The results demonstrate the effectiveness of local injection of MSCs into the rotator cuff tendon. SIGNIFICANCE: The results of this study suggest that ultrasound-guided umbilical cord blood-derived mesenchymal stem cell injection may be a useful conservative treatment for full-thickness rotator cuff tendon tear repair. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | AlphaMed Press | - |
dc.relation.isPartOf | STEM CELLS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cord Blood Stem Cell Transplantation* | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Heterografts | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mesenchymal Stem Cell Transplantation* | - |
dc.subject.MESH | Rabbits | - |
dc.subject.MESH | Rotator Cuff* | - |
dc.subject.MESH | Tendon Injuries/diagnostic imaging | - |
dc.subject.MESH | Tendon Injuries/therapy* | - |
dc.subject.MESH | Ultrasonography | - |
dc.title | Regeneration of Full-Thickness Rotator Cuff Tendon Tear After Ultrasound-Guided Injection With Umbilical Cord Blood-Derived Mesenchymal Stem Cells in a Rabbit Model | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Rehabilitation Medicine | - |
dc.contributor.googleauthor | GI-YOUNG PARK | - |
dc.contributor.googleauthor | DONG RAK KWON | - |
dc.contributor.googleauthor | SANG CHUL LEE | - |
dc.identifier.doi | 10.5966/sctm.2015-0040 | - |
dc.contributor.localId | A02832 | - |
dc.relation.journalcode | J02683 | - |
dc.identifier.eissn | 1549-4918 | - |
dc.identifier.pmid | 26371340 | - |
dc.subject.keyword | Injection | - |
dc.subject.keyword | Mesenchymal stem cells | - |
dc.subject.keyword | Rotator cuff | - |
dc.subject.keyword | Tendon | - |
dc.subject.keyword | Ultrasound | - |
dc.contributor.alternativeName | Lee, Sang Chul | - |
dc.contributor.affiliatedAuthor | Lee, Sang Chul | - |
dc.citation.volume | 4 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1344 | - |
dc.citation.endPage | 1351 | - |
dc.identifier.bibliographicCitation | STEM CELLS, Vol.4(11) : 1344-1351, 2015 | - |
dc.identifier.rimsid | 41242 | - |
dc.type.rims | ART | - |
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