Cited 88 times in
Pulp-dentin Regeneration: Current State and Future Prospects
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김의성 | - |
dc.date.accessioned | 2018-03-26T16:53:41Z | - |
dc.date.available | 2018-03-26T16:53:41Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0022-0345 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/156929 | - |
dc.description.abstract | The goal of regenerative endodontics is to reinstate normal pulp function in necrotic and infected teeth that would result in reestablishment of protective functions, including innate pulp immunity, pulp repair through mineralization, and pulp sensibility. In the unique microenvironment of the dental pulp, the triad of tissue engineering would require infection control, biomaterials, and stem cells. Although revascularization is successful in resolving apical periodontitis, multiple studies suggest that it alone does not support pulp-dentin regeneration. More recently, cell-based approaches in endodontic regeneration based on pulpal mesenchymal stem cells (MSCs) have demonstrated promising results in terms of pulp-dentin regeneration in vivo through autologous transplantation. Although pulpal regeneration requires the cell-based approach, several challenges in clinical translation must be overcome-including aging-associated phenotypic changes in pulpal MSCs, availability of tissue sources, and safety and regulation involved with expansion of MSCs in laboratories. Allotransplantation of MSCs may alleviate some of these obstacles, although the long-term stability of MSCs and efficacy in pulp-dentin regeneration demand further investigation. For an alternative source of MSCs, our laboratory developed induced MSCs (iMSCs) from primary human keratinocytes through epithelial-mesenchymal transition by modulating the epithelial plasticity genes. Initially, we showed that overexpression of ΔNp63α, a major isoform of the p63 gene, led to epithelial-mesenchymal transition and acquisition of stem characteristics. More recently, iMSCs were generated by transient knockdown of all p63 isoforms through siRNA, further simplifying the protocol and resolving the potential safety issues of viral vectors. These cells may be useful for patients who lack tissue sources for endogenous MSCs. Further research will elucidate the level of potency of these iMSCs and assess their transdifferentiation capacities into functional odontoblasts when transplanted into the root canal microenvironment. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Sage | - |
dc.relation.isPartOf | JOURNAL OF DENTAL RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Dental Pulp/physiology* | - |
dc.subject.MESH | Dentin/physiology* | - |
dc.subject.MESH | Guided Tissue Regeneration, Periodontal/methods | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Mesenchymal Stem Cell Transplantation | - |
dc.subject.MESH | Mesenchymal Stromal Cells/physiology | - |
dc.subject.MESH | Regeneration/physiology | - |
dc.subject.MESH | Tissue Engineering*/methods | - |
dc.title | Pulp-dentin Regeneration: Current State and Future Prospects | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry | - |
dc.contributor.department | Dept. of Conservative Dentistry | - |
dc.contributor.googleauthor | Y. Cao | - |
dc.contributor.googleauthor | M. Song | - |
dc.contributor.googleauthor | E. Kim | - |
dc.contributor.googleauthor | W. Shon | - |
dc.contributor.googleauthor | N. Chugal | - |
dc.contributor.googleauthor | G. Bogen | - |
dc.contributor.googleauthor | L. Lin | - |
dc.contributor.googleauthor | R.H. Kim | - |
dc.contributor.googleauthor | N.-H. Park | - |
dc.contributor.googleauthor | M.K. Kang | - |
dc.identifier.doi | 10.1177/0022034515601658 | - |
dc.contributor.localId | A00833 | - |
dc.relation.journalcode | J01367 | - |
dc.identifier.eissn | 1544-0591 | - |
dc.identifier.pmid | 26310721 | - |
dc.identifier.url | http://journals.sagepub.com/doi/abs/10.1177/0022034515601658 | - |
dc.subject.keyword | biocompatible materials | - |
dc.subject.keyword | cell- and tissue-based therapy | - |
dc.subject.keyword | dental pulp calcification | - |
dc.subject.keyword | endodontics | - |
dc.subject.keyword | epithelial-mesenchymal transition | - |
dc.subject.keyword | stem cells | - |
dc.contributor.alternativeName | Kim, Eui Seong | - |
dc.contributor.affiliatedAuthor | Kim, Eui Seong | - |
dc.citation.volume | 94 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1544 | - |
dc.citation.endPage | 1551 | - |
dc.identifier.bibliographicCitation | JOURNAL OF DENTAL RESEARCH, Vol.94(11) : 1544-1551, 2015 | - |
dc.identifier.rimsid | 41238 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.