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Association of Body Fat Percentage and Waist-hip Ratio With Brain Cortical Thickness: A Study Among 1777 Cognitively Normal Subjects

Authors
 Hee Jin Kim  ;  Changsoo Kim  ;  Seun Jeon  ;  Mira Kang  ;  Yeo Jin Kim  ;  Jong-Min Lee  ;  Hee-Young Shin  ;  Hanna Cho  ;  Byoung Seok Ye  ;  Jung-Hyun Kim  ;  Eun Young Jang  ;  Jaelim Cho  ;  Duk L. Na  ;  Kathryn M. Rexrode  ;  Sang Won Seo 
Citation
 ALZHEIMER DISEASE & ASSOCIATED DISORDERS, Vol.29(4) : 279-286, 2015 
Journal Title
 ALZHEIMER DISEASE & ASSOCIATED DISORDERS 
ISSN
 0893-0341 
Issue Date
2015
MeSH
Abdominal Fat/metabolism ; Abdominal Fat/pathology ; Adipose Tissue/metabolism* ; Adipose Tissue/pathology* ; Aged ; Aged, 80 and over ; Body Composition/physiology* ; Cerebral Cortex/pathology* ; Cognition/physiology* ; Cross-Sectional Studies ; Female ; Humans ; Magnetic Resonance Imaging/trends ; Male ; Middle Aged ; Organ Size ; Waist-Hip Ratio/trends*
Keywords
cortical thickness ; body fat percentage ; waist hip ratio ; MRI ; surface-based morphometric analysis
Abstract
BACKGROUND: Increasing evidence has emerged that there is a link between body weight and the risk of developing dementia. However, the relationship between adiposity and brain structure has not yet been fully elucidated. We aimed to evaluate the association of body fat composition with cortical thickness in cognitively normal subjects. METHODS: In total, 1777 (887 men and 890 women) cognitively normal subjects, aged 45 years or older, were recruited from the Health Promotion Center in South Korea. Medical records including 3-dimensional magnetic resonance imaging, body fat percentage, waist-hip ratio (WHR), and other factors were reviewed. RESULTS: In men, the percentage of fat was positively associated with cortical thickness and the highest WHR group showed significantly decreased cortical thickness compared with the reference group. WHR showed an inverted U-shaped association with total cortical thickness and frontal lobe thickness in men. Among women, there was no significant association. CONCLUSIONS: Our findings suggest that in men, body fat is positively associated with cortical thickness, whereas abdominal fat is negatively associated with cortical thickness.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00002093-201510000-00002&LSLINK=80&D=ovft
DOI
10.1097/WAD.0000000000000079
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Soo(김창수) ORCID logo https://orcid.org/0000-0002-5940-5649
Ye, Byoung Seok(예병석) ORCID logo https://orcid.org/0000-0003-0187-8440
Cho, Jae Lim(조재림)
Cho, Hanna(조한나) ORCID logo https://orcid.org/0000-0001-5936-1546
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/156923
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