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Association Between Obesity and BRAFV600E Mutation Status in Patients with Papillary Thyroid Cancer

 Jandee Lee  ;  Cho Rok Lee  ;  Cheol Ryong Ku  ;  Sang-Wook Kang  ;  Jong Ju Jeong  ;  Dong Yeob Shin  ;  Kee-Hyun Nam  ;  Sang Geun Jung  ;  Eun Jig Lee  ;  Woong Youn Chung  ;  Young Suk Jo 
 Annals of Surgical Oncology, Vol.22(Suppl 3) : S683-S690, 2015 
Journal Title
 Annals of Surgical Oncology 
Issue Date
Adult ; Aged ; Biomarkers, Tumor/genetics* ; Body Mass Index ; Carcinoma, Papillary/etiology* ; Carcinoma, Papillary/pathology ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Mutation/genetics* ; Neoplasm Staging ; Obesity/complications ; Obesity/genetics* ; Prognosis ; Proto-Oncogene Proteins B-raf/genetics* ; Retrospective Studies ; Thyroid Neoplasms/etiology* ; Thyroid Neoplasms/pathology
BACKGROUND: The prevalence of papillary thyroid cancer (PTC) is thought to be related to obesity, which affects the prognosis for PTC patients. However, the mechanisms implicated in the relationship between obesity and PTC is a matter for debate. In this study, we aimed to gain insight into the relationship between obesity and the clinicopathological features of PTC, including the BRAFV600E mutation. METHODS: The medical records of 1121 PTC patients were reviewed and the relationships between anthropometric factors, biochemical parameters, and clinicopathological parameters, including BRAFV600E mutation status, were analyzed. RESULTS: Body mass index (BMI) showed a strong association with advanced TNM stage (p < 0.001) and BRAFV600E mutation status (p = 0.008). We also found that BRAFV600E (+) patients had a higher body weight (p = 0.024) and a higher BMI (p = 0.003) than patients with BRAFV600E (-) PTC. In addition, BRAFV600E (+) PTC patients had a significantly higher incidence of extrathyroidal extension (p = 0.025) and more advanced T, N, TNM stage (p < 0.001) than BRAFV600E (-) PTC patients. Consistent with this observation, female BRAFV600E (+) PTC patients had a higher BMI (p = 0.011) and more aggressive tumor behaviors than female BRAFV600E (-) PTC patients. In multivariate analysis, BMI was persistently associated with BRAFV600E mutation in the entire cohort (odds ratio [OR] 1.387; 95 % CI 1.036-1.859; p = 0.028) and in the female subcohort (OR 1.221; 95 % CI 1.014-1.631; p = 0.046). CONCLUSION: The positive association between BMI and BRAFV600E supports the hypothesis that excessive bodyweight influences tumor progression.
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1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
강상욱(Kang, Sang Wook) ORCID logo https://orcid.org/0000-0001-5355-833X
구철룡(Ku, Cheol Ryong) ORCID logo https://orcid.org/0000-0001-8693-9630
남기현(Nam, Kee Hyun) ORCID logo https://orcid.org/0000-0002-6852-1190
신동엽(Shin, Dong Yeob) ORCID logo https://orcid.org/0000-0003-1048-7978
이은직(Lee, Eun Jig) ORCID logo https://orcid.org/0000-0002-9876-8370
이잔디(Lee, Jan Dee) ORCID logo https://orcid.org/0000-0003-4090-0049
이초록(Lee, Cho Rok) ORCID logo https://orcid.org/0000-0001-7848-3709
정웅윤(Chung, Woung Youn)
정종주(Jeong, Jong Ju) ORCID logo https://orcid.org/0000-0002-4155-6035
조영석(Jo, Young Suk) ORCID logo https://orcid.org/0000-0001-9926-8389
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