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The role of prophylactic antibiotics on surgical site infection in elective laparoscopic cholecystectomy

 Jae Uk Chong  ;  Jin Hong Lim  ;  Jee Ye Kim  ;  Sung Hoon Kim  ;  Kyung Sik Kim 
 Korean Journal of Hepato-Biliary-Pancreatic Surgery, Vol.19(4) : 188-193, 2015 
Journal Title
Korean Journal of Hepato-Biliary-Pancreatic Surgery(한국간담췌외과학회지)
Issue Date
Antibiotic prophylaxis ; Laparoscopic cholecystectomy ; Nutrition assessment ; Surgical wound infection
BACKGROUNDS/AIMS: Although laparoscopic cholecystectomy is a common and widely accepted technique, the use of prophylactic antibiotics in elective laparoscopic cholecystectomy still remains controversial. The aim of this study is to determine whether prophylactic antibiotics could prevent surgical site infection after elective laparoscopic cholecystectomy and to identify any risk factors for surgical site infection.

METHODS: This study included 471 patients undergoing laparoscopic cholecystectomy between January 2009 and May 2012. Period 1 patients (279) received second generation cephalosporin 1 g intravenously after induction of anesthesia, and Period 2 patients (192) were not given prophylactic antibiotics. The characteristics and surgical site infections of the patients were compared and analyzed.

RESULTS: The overall rate of surgical site infection was 1.69% for the total of 471 patients. The incidence of surgical site infection was similar for the two Periods: 5 of 279 patients (1.79%) in Period 1, 3 of 192 patients (1.56%) in Period 2 (p=0.973). All of the patients with surgical site infections were well treated under conservative treatments without any sequelae. The preoperative albumin level (p=0.023) contributed to surgical site infection.

CONCLUSIONS: Prophylactic antibiotics are not necessary for elective laparoscopic cholecystectomy but patients in poor nutritional state with low albumin level should consider prophylactic antibiotics.
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1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Sik(김경식) ORCID logo https://orcid.org/0000-0001-9498-284X
Kim, Jee Ye(김지예) ORCID logo https://orcid.org/0000-0003-3936-4410
Lim, Jin Hong(임진홍)
Chong, Jae Uk(정재욱)
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