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Acceleration of Bone Regeneration by BMP-2-Loaded Collagenated Biphasic Calcium Phosphate in Rabbit Sinus

DC Field Value Language
dc.contributor.author이중석-
dc.contributor.author정의원-
dc.contributor.author차재국-
dc.contributor.author최성호-
dc.date.accessioned2018-03-26T16:46:46Z-
dc.date.available2018-03-26T16:46:46Z-
dc.date.issued2015-
dc.identifier.issn1523-0899-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/156810-
dc.description.abstractPURPOSE: The objective of this study was to determine the effectiveness of collagenated biphasic calcium phosphate (CBCP) as a carrier for bone morphogenetic protein-2 (BMP-2) at the early stage of healing in rabbit sinus. MATERIAL AND METHODS: In 16 rabbits, BMP-2-loaded CBCP was grafted into one sinus (the BMP group) and saline-soaked CBCP was grafted into another sinus (the CTL group). The groups were assigned randomly. After 2 weeks (n = 8) or 4 weeks (n = 8), radiographic and histological analysis was performed. RESULTS: Total augmented volume was significantly larger in the BMP group at both healing periods. Furthermore, new bone volume was significantly greater in the BMP group at 4 weeks. Marked bone formation near the schneiderian membrane was found in the BMP groups at the early healing period. At 4 weeks, evenly distributed new bone was observed in the BMP group, whereas the new bone was sparsely distributed in the central portion in the CTL group. CONCLUSION: It can be concluded that the addition of BMP-2 to CBCP resulted in a greater initial augmented volume as a result of postoperative swelling, which is replaced by early bone formation, and it was prominent near the Schneiderian membrane.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherJohn Wiley & Sons, Inc-
dc.relation.isPartOfCLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAbsorbable Implants-
dc.subject.MESHAnimals-
dc.subject.MESHBone Morphogenetic Proteins/pharmacology*-
dc.subject.MESHBone Regeneration/drug effects*-
dc.subject.MESHCollagen/pharmacology*-
dc.subject.MESHHydroxyapatites/pharmacology*-
dc.subject.MESHImaging, Three-Dimensional-
dc.subject.MESHMale-
dc.subject.MESHNasal Mucosa/drug effects-
dc.subject.MESHRabbits-
dc.subject.MESHRandom Allocation-
dc.subject.MESHSinus Floor Augmentation/methods*-
dc.subject.MESHSurgical Flaps-
dc.subject.MESHWound Healing/physiology-
dc.subject.MESHX-Ray Microtomography-
dc.titleAcceleration of Bone Regeneration by BMP-2-Loaded Collagenated Biphasic Calcium Phosphate in Rabbit Sinus-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry-
dc.contributor.departmentDept. of Periodontology-
dc.contributor.googleauthorJung-Soo Kim-
dc.contributor.googleauthorJae-Kook Cha-
dc.contributor.googleauthorAh-Ran Cho-
dc.contributor.googleauthorMin-Soo Kim-
dc.contributor.googleauthorJung-Seok Lee-
dc.contributor.googleauthorJi-Youn Hong-
dc.contributor.googleauthorSeong-Ho Choi-
dc.contributor.googleauthorUi-Won Jung-
dc.identifier.doi10.1111/cid.12223-
dc.contributor.localIdA03185-
dc.contributor.localIdA03692-
dc.contributor.localIdA04004-
dc.contributor.localIdA04081-
dc.relation.journalcodeJ00580-
dc.identifier.eissn1708-8208-
dc.identifier.pmid24673932-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/cid.12223/abstract-
dc.subject.keywordbone substitutes-
dc.subject.keywordbone tissue engineering-
dc.subject.keywordbone regeneration-
dc.subject.keywordsinus augmentation-
dc.contributor.alternativeNameLee, Jung Seok-
dc.contributor.alternativeNameJung, Ui Won-
dc.contributor.alternativeNameCha, Jae Kook-
dc.contributor.alternativeNameChoi, Seong Ho-
dc.contributor.affiliatedAuthorLee, Jung Seok-
dc.contributor.affiliatedAuthorJung, Ui Won-
dc.contributor.affiliatedAuthorCha, Jae Kook-
dc.contributor.affiliatedAuthorChoi, Seong Ho-
dc.citation.volume17-
dc.citation.number6-
dc.citation.startPage1103-
dc.citation.endPage1113-
dc.identifier.bibliographicCitationCLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH, Vol.17(6) : 1103-1113, 2015-
dc.identifier.rimsid39938-
dc.type.rimsART-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers

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