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Preoperative Underweight Patients with Upper Tract Urothelial Carcinoma Survive Less after Radical Nephroureterectomy

Authors
 Ho Won Kang  ;  Hae Do Jung  ;  Yun-Sok Ha  ;  Tae-Hwan Kim  ;  Tae Gyun Kwon  ;  Seok-Soo Byun  ;  Seok-Joong Yun  ;  Wun-Jae Kim  ;  Young Deuk Choi 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.30(10) : 1483-1489, 2015 
Journal Title
 JOURNAL OF KOREAN MEDICAL SCIENCE 
ISSN
 1011-8934 
Issue Date
2015
MeSH
Aged ; Asian Continental Ancestry Group ; Body Mass Index ; Carcinoma, Transitional Cell/mortality* ; Cystectomy/mortality* ; Female ; Humans ; Kidney Pelvis/surgery ; Male ; Nephrectomy/mortality* ; Republic of Korea ; Retrospective Studies ; Thinness/mortality* ; Ureter/surgery ; Urinary Bladder/surgery ; Urologic Neoplasms/mortality* ; Urologic Neoplasms/pathology ; Urologic Neoplasms/surgery* ; Urothelium/pathology ; Urothelium/surgery*
Keywords
Body Mass Index ; Carcinoma, Transitional Cell ; Nephroureterectomy ; Survival ; Upper Urinary Tract
Abstract
The prognostic impact of body mass index (BMI) in patients with upper tract urothelial carcinoma (UTUC) is an ongoing debate. Our study aimed to investigate the prognostic role of BMI in patients treated with radical nephroureterectomy (RNU) for UTUC from a multi-institutional Korean collaboration. We retrospectively reviewed data from 440 patients who underwent RNU for UTUC at four institutions in Korea. To avoid biasing the survival estimates, patients who had previous or concomitant muscle-invasive bladder tumors were excluded. BMI was categorized into approximate quartiles with the lowest quartile assigned to the reference group. Kaplan-Meier and multivariate Cox regression analyses were performed to assess the influence of BMI on survival. The lower quartile BMI group showed significantly increased overall mortality (OM) and cancer specific mortality (CSM) compared to the 25%-50% quartiles and upper quartile BMI groups. Kaplan-Meier estimates showed similar results. Based on multivariate Cox regression analysis, preoperative BMI as a continuous variable was an independent predictor for OM and CSM. In conclusion, preoperative underweight patients with UTUC in Korea survive less after RNU. Preoperative BMI may provide additional prognostic information to establish risk factors.
Files in This Item:
T201504477.pdf Download
DOI
10.3346/jkms.2015.30.10.1483
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Jung, Hae Do(정해도)
Choi, Young Deuk(최영득) ORCID logo https://orcid.org/0000-0002-8545-5797
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/156757
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