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Serum interleukin-27 expression in patients with myasthenia gravis

Authors
 Ha-Neul Jeong  ;  Jung Hwan Lee  ;  Bum Chun Suh  ;  Young-Chul Choi 
Citation
 JOURNAL OF NEUROIMMUNOLOGY, Vol.288 : 120-122, 2015 
Journal Title
 JOURNAL OF NEUROIMMUNOLOGY 
ISSN
 0165-5728 
Issue Date
2015
MeSH
Adult ; Female ; Humans ; Interleukins/blood* ; Male ; Middle Aged ; Myasthenia Gravis/blood*
Keywords
Interleukin-27 ; Myasthenia gravis ; Pathogenesis
Abstract
Myasthenia gravis (MG)(1) is an autoimmune disease directed at the neuromuscular junction, and cytokines are thought to contribute to its immunopathogenesis. Interleukin-27 (IL-27)(2) plays a complex and pleiotropic role in immune responses associated with T helper cells. To assess the role of IL-27 in MG, we determined serum IL-27 levels in MG patients (n=32) compared to healthy controls (n=50). The median serum IL-27 level was significantly higher in MG patients (35.947pg/mL) than in controls (19.885pg/mL). Furthermore, serum IL-27 was significantly higher in early onset MG. This study suggests the possibility that IL-27 might contribute to MG pathogenesis or immunoregulation.
Full Text
http://www.sciencedirect.com/science/article/pii/S016557281530045X
DOI
10.1016/j.jneuroim.2015.09.010
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Jung Hwan(이정환)
Choi, Young Chul(최영철) ORCID logo https://orcid.org/0000-0001-5525-6861
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/156734
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