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Different effects of resveratrol on early and late passage mesenchymal stem cells through β-catenin regulation

DC FieldValueLanguage
dc.contributor.author박광환-
dc.contributor.author윤동석-
dc.contributor.author이진우-
dc.contributor.author최유림-
dc.date.accessioned2018-03-26T16:42:08Z-
dc.date.available2018-03-26T16:42:08Z-
dc.date.issued2015-
dc.identifier.issn0006-291X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/156729-
dc.description.abstractResveratrol is a sirtuin 1 (SIRT1) activator and can function as an anti-inflammatory and antioxidant factor. In mesenchymal stem cells (MSCs), resveratrol enhances the proliferation and differentiation potential and has an anti-aging effect. However, contradictory effects of resveratrol on MSC cultures have been reported. In this study, we found that resveratrol had different effects on MSC cultures according to their cell passage and SIRT1 expression. Resveratrol enhanced the self-renewal potential and multipotency of early passage MSCs, but accelerated cellular senescence of late passage MSCs. In early passage MSCs expressing SIRT1, resveratrol decreased ERK and GSK-3β phosphorylation, suppressing β-catenin activity. In contrast, in late passage MSCs, which did not express SIRT1, resveratrol increased ERK and GSK-3β phosphorylation, activating β-catenin. We confirmed that SIRT1-deficient early passage MSCs treated with resveratrol lost their self-renewal potential and multipotency, and became senescent due to increased β-catenin activity. Sustained treatment with resveratrol at early passages maintained the self-renewal potential and multipotency of MSCs up to passage 10. Our findings suggest that resveratrol can be effectively applied to early passage MSC cultures, whereas parameters such as cell passage and SIRT1 expression must be taken into consideration before applying resveratrol to late passage MSCs.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHCellular Senescence/drug effects-
dc.subject.MESHHumans-
dc.subject.MESHMesenchymal Stromal Cells/drug effects*-
dc.subject.MESHMesenchymal Stromal Cells/metabolism-
dc.subject.MESHStilbenes/pharmacology*-
dc.subject.MESHbeta Catenin/metabolism*-
dc.titleDifferent effects of resveratrol on early and late passage mesenchymal stem cells through β-catenin regulation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Orthopedic Surgery-
dc.contributor.googleauthorDong Suk Yoon-
dc.contributor.googleauthorYoorim Choi-
dc.contributor.googleauthorSeong Mi Choi-
dc.contributor.googleauthorKwang Hwan Park-
dc.contributor.googleauthorJin Woo Lee-
dc.identifier.doi10.1016/j.bbrc.2015.10.017-
dc.contributor.localIdA01437-
dc.contributor.localIdA02547-
dc.contributor.localIdA03230-
dc.contributor.localIdA04133-
dc.relation.journalcodeJ00281-
dc.identifier.eissn1090-2104-
dc.identifier.pmid26456654-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0006291X1530721X-
dc.subject.keywordCellular senescence-
dc.subject.keywordMesenchymal stem cells-
dc.subject.keywordResveratrol-
dc.subject.keywordSIRT1-
dc.subject.keywordβ-catenin-
dc.contributor.alternativeNamePark, Kwang Hwan-
dc.contributor.alternativeNameYoon, Dong Suk-
dc.contributor.alternativeNameLee, Jin Woo-
dc.contributor.alternativeNameChoi, Yoo Rim-
dc.contributor.affiliatedAuthorPark, Kwang Hwan-
dc.contributor.affiliatedAuthorYoon, Dong Suk-
dc.contributor.affiliatedAuthorLee, Jin Woo-
dc.contributor.affiliatedAuthorChoi, Yoo Rim-
dc.citation.volume467-
dc.citation.number4-
dc.citation.startPage1026-
dc.citation.endPage1032-
dc.identifier.bibliographicCitationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.467(4) : 1026-1032, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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