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Postoperative Effects of Thiopurines in Patients with Intestinal Behçet's Disease

 Hye Won Lee  ;  Jae Hee Cheon  ;  Hyun Jung Lee  ;  Soo Jung Park  ;  Sung Pil Hong  ;  Tae Il Kim  ;  Won Ho Kim 
 Digestive Diseases and Sciences, Vol.60(12) : 3721-3727, 2015 
Journal Title
 Digestive Diseases and Sciences 
Issue Date
Adolescent Adult Aged Aminosalicylic Acids/therapeutic use* Azathioprine/therapeutic use* ; Behcet Syndrome/drug therapy* ; Female ; Humans ; Immunosuppressive Agents/therapeutic use* ; Male ; Mercaptopurine/therapeutic use* ; Middle Aged ; Recurrence ; Retrospective Studies ; Young Adult
5-ASA ; Behçet’s disease ; Clinical recurrence ; Intestinal Behçet’s disease ; Surgery ; Thiopurine
BACKGROUND: No studies have heretofore specifically focused on the efficacy of postoperative thiopurine therapy in intestinal Behçet's disease (BD). We conducted this study to assess the clinical effects of postoperative thiopurines in patients with intestinal BD. METHODS: We reviewed the medical records of all patients with intestinal BD who had undergone bowel resection surgery in a single tertiary academic medical center between 1991 and 2013. The cumulative probabilities of clinical recurrence were calculated using the Kaplan-Meier method, and predictive factors for recurrence were assessed by multivariate analysis. RESULTS: A total of 77 patients with intestinal BD received 5-ASA (n = 50, 64.9%) or thiopurine (n = 27, 35.1%) therapy after surgery at our center. The postoperative recurrence rate was lower in patients who received postoperative thiopurines (P = 0.050). The hazard ratio for recurrence was 0.636 (95% confidence interval 0.130-1.016, P = 0.053) for postoperative thiopurine use compared with postoperative 5-ASA. However, the rates of re-operation, re-admission, and death were not significantly different between the 5-ASA and thiopurine groups. CONCLUSIONS: Thiopurine therapy after surgery exhibited a modest effect in preventing recurrence in intestinal BD patients. More patients, long-term follow-up, and a randomized controlled design are necessary to validate the effectiveness of postoperative thiopurines in patients with this disease.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Won Ho(김원호) ORCID logo https://orcid.org/0000-0002-5682-9972
Kim, Tae Il(김태일) ORCID logo https://orcid.org/0000-0003-4807-890X
Park, Soo Jung(박수정)
Lee, Hyun Jung(이현정)
Lee, Hye Won(이혜원) ORCID logo https://orcid.org/0000-0002-3552-3560
Cheon, Jae Hee(천재희) ORCID logo https://orcid.org/0000-0002-2282-8904
Hong, Sung Pil(홍성필)
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