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Clinical impact of high mobility group box 1 protein in epithelial ovarian cancer

 Jiheum Paek  ;  Maria Lee  ;  Eun Ji Nam  ;  Sang Wun Kim  ;  Young Tae Kim 
 Archives of Gynecology and Obstetrics, Vol.293(3) : 645-650, 2016 
Journal Title
 Archives of Gynecology and Obstetrics 
Issue Date
PURPOSE: The aim of this study was to confirm the expression of high mobility group box 1 (HMGB1) in patients with epithelial ovarian cancer (EOC) and to evaluate the prognostic significance of HMGB1. METHODS: A total of 74 patients with EOC comprised our cohort. Retrospectively collected tissue microarray from EOC patients treated with debulking surgery followed by taxane and platinum chemotherapy were analyzed for evaluation of the prognostic significance of HMGB1. Expression of HMGB1 was assessed by immunohistochemistry. RESULTS: The positive staining was detected in 80% of EOC patients and the rate of high HMGB1 expression was 42%. In advanced stage, patients with high HMGB1 expression showed a poorer prognosis than low HMGB1 expression group [median progression-free survival (PFS), 10.8 vs. 21.7 months, P = 0.005]. High HMGB1 expression was an independent predictor for PFS (P = 0.024). CONCLUSIONS: HMGB1 expression is expected as a promising biomarker for EOC and further studies are needed to assess potential roles in EOC.
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1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
김상운(Kim, Sang Wun) ORCID logo https://orcid.org/0000-0002-8342-8701
김영태(Kim, Young Tae) ORCID logo https://orcid.org/0000-0002-7347-1052
남은지(Nam, Eun Ji)
백지흠(Paek, Ji Heum)
이마리아(Lee, Maria)
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