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직장암 치료 중 진단된 만성호중구성백혈병 1예

Other Titles
 Incidentally Found Chronic Neutrophilic Leukemia in a Patient with Rectal Cancer 
 김석형  ;  박해열  ;  황창혁  ;  정영학  ;  이민주  ;  최성은  ;  김유리 
 Korean Journal of Medicine, Vol.90(1) : 59-62, 2016 
Journal Title
Korean Journal of Medicine
Issue Date
증례는 감염 및 악성종양과 동반되어 백혈병양 반응과의 감별이 어려웠고, 또한 악성종양의 전이와 유사하게 종괴를 형성하여 더욱 감별이 어려웠던 CNL 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

Chronic neutrophilic leukemia (CNL) is a rare myeloproliferative neoplasm characterized by sustained neutrophilia, splenomegaly, and hypercellular bone marrow without Philadelphia chromosome. Diagnosis of CNL requires exclusion of identifiable causes of reactive neutrophilia, such as infection and tumors. Our patient presented with general weakness and weight loss. Computed tomography (CT) showed a mass in the distal rectum, which was confirmed to be an adenocarcinoma by colonoscopic biopsy. Positron emission tomography-CT showed multiple liver, bone, and lymph node metastases. Liver and lymph node biopsies revealed neutrophilic infiltration with no evidence of adenocarcinoma. The pathological findings of the bone marrow were compatible with CNL. Cytogenetic analysis revealed a normal karyotype, and molecular analysis was negative for BCR/ABL. Here, we present a 73 year-old man diagnosed with concurrent CNL and rectal cancer.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seok Hyung(김석형)
Kim, Yu Ri(김유리) ORCID logo https://orcid.org/0000-0001-5505-0142
Park, Hae Yeul(박해열)
Lee, Minjoo(이민주)
Chung, Young Hak(정영학)
Choi, Sung Eun(최성은) ORCID logo https://orcid.org/0000-0002-6955-658X
Hwang, Changhyeok(황창혁)
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