175 269

Cited 0 times in

Epigenetic regulation of long noncoding RNA UCA1 by SATB1 in breast cancer

Authors
 Jong-Joo Lee  ;  Mikyoung Kim  ;  Hyoung-Pyo Kim 
Citation
 BMB REPORTS, Vol.49(10) : 578-583, 2016 
Journal Title
BMB REPORTS
ISSN
 1976-6696 
Issue Date
2016
Abstract
Special AT-rich sequence binding protein 1 (SATB1) is a nuclear matrix-associated DNA-binding protein that functions as a chromatin organizer. SATB1 is highly expressed in aggressive breast cancer cells and promotes growth and metastasis by reprograming gene expression. Through genomewide cross-examination of gene expression and histone methylation, we identified SATB1 target genes for which expression is associated with altered epigenetic marks. Among the identified genes, long noncoding RNA urothelial carcinoma-associated 1 (UCA1) was upregulated by SATB1 depletion. Upregulation of UCA1 coincided with increased H3K4 trimethylation (H3K4me3) levels and decreased H3K27 trimethylation (H3K27me3) levels. Our study showed that SATB1 binds to the upstream region of UCA1 in vivo, and that its promoter activity increases with SATB1 depletion. Furthermore, simultaneous depletion of SATB1 and UCA1 potentiated suppression of tumor growth and cell survival. Thus, SATB1 repressed the expression of oncogenic UCA1, suppressing growth and survival of breast cancer cells. [BMB Reports 2016; 49(10): 578-583].
Files in This Item:
T201604561.pdf Download
DOI
10.5483/BMBRep.2016.49.10.156
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Environmental Medical Biology (환경의생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Mi Kyoung(김미경)
Kim, Hyoung Pyo(김형표) ORCID logo https://orcid.org/0000-0003-1441-8822
Lee, Jong Joo(이종주)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/155754
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links