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Roflumilast Ameliorates Airway Hyperresponsiveness Caused by Diet-Induced Obesity in a Murine Model

DC Field Value Language
dc.contributor.author박경희-
dc.contributor.author박윤희-
dc.contributor.author박중원-
dc.contributor.author박혜정-
dc.contributor.author심다운-
dc.contributor.author이재현-
dc.contributor.author한희재-
dc.date.accessioned2018-01-23T05:51:28Z-
dc.date.available2018-01-23T05:51:28Z-
dc.date.issued2016-
dc.identifier.issn1044-1549-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/155729-
dc.description.abstractObese patients with asthma respond poorly to conventional asthma medications, resulting in severe symptoms and poor prognosis. Roflumilast, a phosphodiesterase-4 inhibitor that lowers the levels of various substances that are implicated in obese subjects with asthma, may be effective in the treatment of those subjects. We evaluated the potential of roflumilast as a novel therapeutic agent for obese subjects with asthma. We designed three models: diet-induced obesity (DIO); DIO with ovalbumin (OVA); and OVA. We fed C57BL/6J mice a high-fat diet for 3 months with or without OVA sensitization and challenge. Roflumilast or dexamethasone was administered orally three times at 2-day intervals in the last experimental week. Airway hyperresponsiveness resulting from DIO significantly improved in the roflumilast-treated group compared with the dexamethasone-treated groups. Although DIO did not affect the cell proliferation in bronchoalveolar lavage fluid, increased fibrosis was seen in the DIO group, which significantly improved from treatment with roflumilast. DIO-induced changes in adiponectin and leptin levels were improved by roflumilast, whereas dexamethasone aggravated them. mRNA levels and proteins of TNF-α, transforming growth factor-β, IL-1β, and IFN-γ increased in the DIO group and decreased with roflumilast. The reactive oxygen species levels were also increased in the DIO group and decreased by roflumilast. In the DIO plus OVA and OVA models, roflumilast improved Th1 and Th2 cell activation to a greater extent than dexamethasone. Roflumilast is significantly more effective than dexamethasone against airway hyperresponsiveness caused by DIO in the murine model. Roflumilast may represent a promising therapeutic agent for the treatment of obese patients with asthma.-
dc.description.statementOfResponsibilityrestriction-
dc.relation.isPartOfAMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleRoflumilast Ameliorates Airway Hyperresponsiveness Caused by Diet-Induced Obesity in a Murine Model-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorHye Jung Park-
dc.contributor.googleauthorJae-Hyun Lee-
dc.contributor.googleauthorYoon Hee Park-
dc.contributor.googleauthorHeejae Han-
dc.contributor.googleauthorDa Woon Sim-
dc.contributor.googleauthorKyung Hee Park-
dc.contributor.googleauthorJung-Won Park-
dc.identifier.doi10.1165/rcmb.2015-0345OC-
dc.contributor.localIdA01427-
dc.contributor.localIdA05199-
dc.contributor.localIdA01681-
dc.contributor.localIdA01769-
dc.contributor.localIdA05212-
dc.contributor.localIdA04598-
dc.contributor.localIdA03086-
dc.relation.journalcodeJ00113-
dc.identifier.eissn1535-4989-
dc.identifier.pmid26756251-
dc.identifier.urlhttp://www.atsjournals.org/doi/abs/10.1165/rcmb.2015-0345OC-
dc.contributor.alternativeNamePark, Kyung Hee-
dc.contributor.alternativeNamePark, Yoon Hee-
dc.contributor.alternativeNamePark, Jung Won-
dc.contributor.alternativeNamePark, Hye Jung-
dc.contributor.alternativeNameSim, Da Woon-
dc.contributor.alternativeNameLee, Jae Hyun-
dc.contributor.alternativeNameHan, Heejae-
dc.contributor.affiliatedAuthorPark, Kyung Hee-
dc.contributor.affiliatedAuthorPark, Yoon Hee-
dc.contributor.affiliatedAuthorPark, Jung Won-
dc.contributor.affiliatedAuthorPark, Hye Jung-
dc.contributor.affiliatedAuthorHan, Heejae-
dc.contributor.affiliatedAuthorSim, Da Woon-
dc.contributor.affiliatedAuthorLee, Jae Hyun-
dc.citation.volume55-
dc.citation.number1-
dc.citation.startPage82-
dc.citation.endPage91-
dc.identifier.bibliographicCitationAMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, Vol.55(1) : 82-91, 2016-
dc.identifier.rimsid48186-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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