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Human Embryonic Stem Cell-Derived Endothelial Precursor Cell Conditioned Medium Reduces the Thickness of the Capsule Around Silicone Implants in Rats
DC Field | Value | Language |
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dc.contributor.author | 송승용 | - |
dc.date.accessioned | 2018-01-23T05:51:00Z | - |
dc.date.available | 2018-01-23T05:51:00Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0148-7043 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/155712 | - |
dc.description.abstract | BACKGROUND: We postulated that the fibrotic capsule around a silicone implant could be induced by ischemic conditions, based on previous reports that hypoxia is an important microenvironmental factor in the development of tissue fibrosis. OBJECTIVE: This study aimed to determine the effect of human embryonic stem cell (hESC)-derived endothelial precursor cell (EPC) conditioned medium (CM), which has strong angiogenic potential, on the development of capsule around the silicone implant in a rat model. METHODS AND MATERIALS: Three groups had a mini-silicone implant with a smooth surface inserted. In 2 experimental groups, hESC-EPC CM was administered into the subcutaneous pocket either 1 or 2 times. After 2 months, the capsules were harvested and analyzed by histologic examination. RESULTS: There was a significant reduction in the thickness of the peri-implant capsules (P < 0.05) between the control and experimental groups. There is no tendency that hESC-EPC CM reduces inflammatory reaction in early postoperative periods. The experimental group showed increased angiogenesis compared to the control group (P < 0.05). CONCLUSIONS: Tissue hypoxia around the implant may be another cause for the peri-implant capsule. A preventive or therapeutic strategy to decrease capsular contracture by relieving the ischemic condition around the implant can be investigated in the future. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.relation.isPartOf | ANNALS OF PLASTIC SURGERY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Breast Implantation/instrumentation* | - |
dc.subject.MESH | Breast Implants/adverse effects* | - |
dc.subject.MESH | Culture Media, Conditioned* | - |
dc.subject.MESH | Endothelial Progenitor Cells* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Foreign-Body Reaction/etiology | - |
dc.subject.MESH | Human Embryonic Stem Cells* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypoxia/complications | - |
dc.subject.MESH | Implant Capsular Contracture/etiology | - |
dc.subject.MESH | Implant Capsular Contracture/prevention & control* | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Silicone Gels/adverse effects* | - |
dc.title | Human Embryonic Stem Cell-Derived Endothelial Precursor Cell Conditioned Medium Reduces the Thickness of the Capsule Around Silicone Implants in Rats | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Plastic Surgery & Reconstructive Surgery | - |
dc.contributor.googleauthor | Kim, Chung Hun | - |
dc.contributor.googleauthor | Kim, Dae Hee | - |
dc.contributor.googleauthor | Oh, Seung Hyun | - |
dc.contributor.googleauthor | Song, Seung Yong | - |
dc.identifier.doi | 10.1097/SAP.0000000000000123. | - |
dc.contributor.localId | A02032 | - |
dc.relation.journalcode | J00176 | - |
dc.identifier.eissn | 1536-3708 | - |
dc.identifier.pmid | 25803327 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00000637-201509000-00022&LSLINK=80&D=ovft | - |
dc.subject.keyword | capsular contracture | - |
dc.subject.keyword | hypoxia | - |
dc.subject.keyword | ischemia | - |
dc.subject.keyword | human embryonic stem cell–derived endothelial precursor cell conditioned medium (hESC-EPC CM) | - |
dc.subject.keyword | paracrine system | - |
dc.subject.keyword | fibrosis | - |
dc.contributor.alternativeName | Song, Seung Yong | - |
dc.contributor.affiliatedAuthor | Song, Seung Yong | - |
dc.citation.volume | 75 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 348 | - |
dc.citation.endPage | 352 | - |
dc.identifier.bibliographicCitation | ANNALS OF PLASTIC SURGERY, Vol.75(3) : 348-352, 2015 | - |
dc.identifier.rimsid | 48171 | - |
dc.type.rims | ART | - |
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