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The Tourette International Collaborative Genetics (TIC Genetics) study, finding the genes causing Tourette syndrome: objectives and methods

Authors
 Andrea Dietrich  ;  Thomas V. Fernandez  ;  Robert A. King  ;  Matthew W. State  ;  Jay A. Tischfield  ;  Pieter J. Hoekstra  ;  Gary A. Heiman  ;  the TIC Genetics Collaborative Group 
Citation
 EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, Vol.24(2) : 141-151, 2015 
Journal Title
 EUROPEAN CHILD & ADOLESCENT PSYCHIATRY 
ISSN
 1018-8827 
Issue Date
2015
MeSH
Attention Deficit Disorder with Hyperactivity/complications* ; Attention Deficit Disorder with Hyperactivity/psychology ; Child ; Cooperative Behavior ; Female ; Gene-Environment Interaction ; Genetic Linkage ; Genetic Predisposition to Disease ; Genomics ; Humans ; Obsessive-Compulsive Disorder/complications* ; Obsessive-Compulsive Disorder/psychology ; Pedigree ; Tic Disorders/complications* ; Tic Disorders/psychology ; Tics/complications* ; Tics/psychology ; Tourette Syndrome/genetics* ; Tourette Syndrome/psychology
Keywords
Genes ; Methods ; Multiplex families ; Rare variants ; Repository ; Tourette syndrome ; Trios
Abstract
Tourette syndrome (TS) is a neuropsychiatric disorder characterized by recurrent motor and vocal tics, often accompanied by obsessive-compulsive disorder and/or attention-deficit/hyperactivity disorder. While the evidence for a genetic contribution is strong, its exact nature has yet to be clarified fully. There is now mounting evidence that the genetic risks for TS include both common and rare variants and may involve complex multigenic inheritance or, in rare cases, a single major gene. Based on recent progress in many other common disorders with apparently similar genetic architectures, it is clear that large patient cohorts and open-access repositories will be essential to further advance the field. To that end, the large multicenter Tourette International Collaborative Genetics (TIC Genetics) study was established. The goal of the TIC Genetics study is to undertake a comprehensive gene discovery effort, focusing both on familial genetic variants with large effects within multiply affected pedigrees and on de novo mutations ascertained through the analysis of apparently simplex parent-child trios with non-familial tics. The clinical data and biomaterials (DNA, transformed cell lines, RNA) are part of a sharing repository located within the National Institute for Mental Health Center for Collaborative Genomics Research on Mental Disorders, USA, and will be made available to the broad scientific community. This resource will ultimately facilitate better understanding of the pathophysiology of TS and related disorders and the development of novel therapies. Here, we describe the objectives and methods of the TIC Genetics study as a reference for future studies from our group and to facilitate collaboration between genetics consortia in the field of TS.
Files in This Item:
T201506564.pdf Download
DOI
10.1007/s00787-014-0543-x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Song, Dong Ho(송동호) ORCID logo https://orcid.org/0000-0002-9647-3130
Shin, Eun Young(신은영)
Cheon, Keun Ah(천근아) ORCID logo https://orcid.org/0000-0001-7113-9286
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/155687
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