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Cross-sectional and longitudinal association between hemoglobin concentrations and hypertension incidence

Other Titles
 헤모글로빈 농도와 고혈압 발생률과의 관련성 :일반인을 대상으로 한 코호트 
Authors
 Na Hyun Kim 
Issue Date
2016
Description
보건학과/박사
Abstract
Objective: To investigate cross-sectional and longitudinal associations between hemoglobin concentration and hypertension in a Korean community population. Methods: Between 2006 and 2013, this study examined 4,899 participants with a mean age of 56.6 (35-88) years in a rural community. After excluding 298 participants with a history of myocardial infarction or stroke and 215 participants with abnormally low hemoglobin levels (men <13 g/dL and women <11 g/dL), this cross-sectional analysis was performed on 1,684 men and 2,809 women. Longitudinal associations were evaluated in 675 men and 1,119 women, after excluding 2,699 participants with hypertension at baseline and those who did not participate in follow-up examinations. Hypertension was defined as systolic blood pressure ≥140 mmHg, diastolic blood pressure ≥90 mmHg, or use of antihypertensive treatment at baseline and follow-up. Results: The mean hemoglobin level was significantly higher in people with hypertension than in those without hypertension (p = 0.003 for men, p = 0.015 for women). Cross-sectional analysis of participants aged under 60 years old revealed an odds ratio (OR) (95% confidence interval [CI]) for hypertension of 1.16 (0.96-1.40) per one standard deviation (SD) increase in hemoglobin concentration (1.2 g/dL) in men after adjusting for age, body mass index, lifestyle factors, comorbidities, serum blood urea nitrogen, and serum creatinine levels. However, the OR (95% CI) for hypertension per one standard deviation (SD) increase in hemoglobin concentration (1.2 g/dL) was 1.28 (1.09-1.50) in women after adjusting for age, body mass index, lifestyle factors, comorbidities, serum blood urea nitrogen, and serum creatinine. In participants over 60 years of age, men (OR1.15, 95% CI 0.93-1.42) and women (OR 0.94, 95% CI 0.78-1.13) had non-significant association with hypertension. In longitudinal analysis for participants aged under 60 years of age, the relative risks (95% CI) for incident hypertension per one SD increase in hemoglobin concentration were 0.96 (0.85 - 1.09) in men and 1.00 (0.91 - 1.10) in women after adjusting for age, body mass index, lifestyle factors, serum blood urea nitrogen, serum creatinine, baseline comorbidities, and baseline blood pressure. In participants aged above 60 years of age, the relative risks (95% CI) for incident hypertension per one SD increase in hemoglobin concentration were 1.01 (0.86 - 1.19) in men and 1.01 (0.85 - 1.19) in women after adjusting for age, body mass index, lifestyle factors, serum blood urea nitrogen, serum creatinine, baseline comorbidities, and baseline blood pressure. Conclusion: The results of this study revealed significant associations between higher hemoglobin concentrations and the prevalence of hypertension and blood pressure among participants less than 60 years of age. However, there was no significant association between higher hemoglobin concentrations and incident hypertension after adjusting for age, body mass index, lifestyles, serum blood urea nitrogen, serum creatinine, diabetes, hypercholesterolemia, and systolic blood pressure, regardless of age.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Others (기타) > 3. Dissertation
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154741
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