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Clinically determined type of 18F-fluoro-2-deoxyglucose uptake as an alternative prognostic marker in resectable pancreatic cancer

Authors
 Jae Uk Chong  ;  Ho Kyoung Hwang  ;  Jin Ho Lee  ;  Mijin Yun  ;  Chang Moo Kang  ;  Woo Jung Lee 
Citation
 PLoS One, Vol.12(2) : e0172606, 2017 
Journal Title
 PLoS One 
Issue Date
2017
MeSH
Aged ; Carcinoma, Pancreatic Ductal/classification ; Carcinoma, Pancreatic Ductal/diagnostic imaging* ; Carcinoma, Pancreatic Ductal/mortality ; Carcinoma, Pancreatic Ductal/surgery ; Disease-Free Survival ; Female ; Fluorodeoxyglucose F18/metabolism ; Fluorodeoxyglucose F18/pharmacokinetics* ; Humans ; Male ; Middle Aged ; Pancreatectomy* ; Pancreatic Neoplasms/classification ; Pancreatic Neoplasms/diagnostic imaging* ; Pancreatic Neoplasms/mortality ; Pancreatic Neoplasms/surgery ; Positron-Emission Tomography/methods* ; Prognosis ; Radiopharmaceuticals/metabolism ; Radiopharmaceuticals/pharmacokinetics* ; Retrospective Studies ; Tumor Burden
Abstract
PURPOSE: To investigate the association between clinical PET (positron emission tomography) type and oncologic outcome in resectable pancreatic cancer. METHODS: Between January 2008 and October 2012, patients who underwent potentially curative resection for resectable pancreatic ductal adenocarcinoma without neoadjuvant treatment were retrospectively investigated. Clinical PET type was defined as follows: pancreatic cancer with similar 18FDG uptake to renal calyx was determined as kidney-type (K-type), and relatively lower 18FDG uptake than that of renal calyx was regarded as Non-K type. RESULTS: A total of 53 patients were enrolled. After agreement-based reclassification, agreement based K-type (aK-type) was noted in 34 patients (64.2%), and agreement based Non-K type (aNon K-type) was found in 19 patients (35.8%). There was a significant difference between aK-type and aNon K-type pancreatic cancer (tumor size (P = 0.030), adjusted CA 19-9 (P = 0.007), maximum standard uptake value (SUVmax,P<0.001), metabolic tumor volume (MTV2.5, P<0.001), total lesion glycolysis (TLG, P<0.001)). K-type pancreatic cancer (n = 31) showed a significantly shorter disease-free time compared with Non-K type (n = 16) (10.8 vs. 24.1 months, P = 0.013). It was also noted that aK-type showed inferior disease-free survival to that of aNon-K type pancreatic cancer (11.9 vs. 28.6 months, P = 0.012). CONCLUSIONS: Clinical PET type is a reliable clinical marker to estimate aggressive tumor biology and can be utilized in predicting tumor recurrence and necessity for postoperative chemotherapy.
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DOI
10.1371/journal.pone.0172606
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
강창무(Kang, Chang Moo) ORCID logo https://orcid.org/0000-0002-5382-4658
윤미진(Yun, Mi Jin) ORCID logo https://orcid.org/0000-0002-1712-163X
이우정(Lee, Woo Jung) ORCID logo https://orcid.org/0000-0001-9273-261X
정재욱(Chong, Jae Uk)
황호경(Hwang, Ho Kyoung) ORCID logo https://orcid.org/0000-0003-4064-7776
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154720
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