88 119

Cited 5 times in

Expression of Autophagy-Related Proteins in Different Types of Thyroid Cancer

 Hye Min Kim  ;  Eun-Sol Kim  ;  Ja Seung Koo 
 International Journal of Molecular Sciences, Vol.18(3) : 1-11, 2017 
Journal Title
 International Journal of Molecular Sciences 
Issue Date
Adenocarcinoma, Follicular/genetics ; Adenocarcinoma, Follicular/metabolism ; Adenocarcinoma, Follicular/pathology* ; Autophagy ; Autophagy-Related Proteins/metabolism* ; Carcinoma/genetics ; Carcinoma/metabolism ; Carcinoma/pathology* ; Carcinoma, Neuroendocrine/genetics ; Carcinoma, Neuroendocrine/metabolism ; Carcinoma, Neuroendocrine/pathology* ; Carcinoma, Papillary ; Humans ; Membrane Proteins/metabolism ; Microtubule-Associated Proteins/metabolism ; Mutation ; Prognosis ; Proto-Oncogene Proteins/metabolism ; Proto-Oncogene Proteins B-raf/genetics ; RNA-Binding Proteins/metabolism ; Survival Analysis ; Thyroid Neoplasms/genetics ; Thyroid Neoplasms/metabolism ; Thyroid Neoplasms/pathology* ; Tissue Array Analysis
autophagy ; pathology ; stroma ; subtype ; thyroid cancer
Thyroid cancer is common type of malignant tumor in humans, and the autophagy status of such tumors may vary according to subtype. This study aimed to investigate the expression and implications of the major autophagy-related molecules light chain (LC) 3A, LC3B, p62, and BNIP-3 in human thyroid carcinoma. Tissue microarrays were constructed from 555 thyroid cancers (papillary thyroid carcinoma (PTC): 342; follicular carcinoma (FC): 112; medullary carcinoma (MC): 70; poorly differentiated carcinoma (PDC): 23; and anaplastic carcinoma (AC): 8) and 152 follicular adenomas (FAs). Expression of autophagy-related molecules (LC3A, LC3B, p62, and BNIP-3) was detected immunohistochemically, and the results were analyzed via comparison with clinicopathologic parameters. Tumoral LC3A and LC3B expressions were the highest in MC (p < 0.001), whereas stromal LC3A expression was higher in AC and PTC (p < 0.001). BNIP-3 expression was absent in MC and AC (p = 0.013). Tumoral LC3A, LC3B, and p62 expressions were higher in conventional type PTC, compared with those in the follicular variant. PTC with the BRAF V600E mutation exhibited higher expression of all autophagy-related proteins relative to PTC without this mutation (p < 0.05). BNIP-3 negativity was associated with capsular invasion in FC (p = 0.001), and p62 negativity was associated with lymph node metastasis in MC (p = 0.006). In a univariate analysis, LC3B negativity was associated with shorter disease-free survival in PTC with the BRAF V600E mutation (p = 0.024). We conclude that the expression of autophagy-related proteins differs according to thyroid cancer subtype.
Files in This Item:
T201700465.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Koo, Ja Seung(구자승) ORCID logo https://orcid.org/0000-0003-4546-4709
Kim, Hye Min(김혜민) ORCID logo https://orcid.org/0000-0002-2899-9480
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.