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Predictors of general discomfort, limitations in activities of daily living and intention of a second donation in unrelated hematopoietic stem cell donation

Authors
 M H Lee  ;  J H Jang  ;  H J Min  ;  H I Jang  ;  J H Nah  ;  C J Lyu  ;  K-S Han  ;  J H Won  ;  Y-H Lee  ;  S Y Chong  ;  Y C Mun  ;  W S Lee  ;  S J Kim  ;  I Kim 
Citation
 Bone Marrow Transplantation, Vol.52(2) : 258-263, 2017 
Journal Title
 Bone Marrow Transplantation 
ISSN
 0268-3369 
Issue Date
2017
MeSH
Activities of Daily Living* ; Adult ; Age Factors ; Female ; Humans ; Male ; Middle Aged ; Peripheral Blood Stem Cells* ; Retrospective Studies ; Sex Factors ; Unrelated Donors*
Abstract
We performed a retrospective study of 1868 consecutive unrelated donors to predict the risk factors related to general discomfort, limitations in activities of daily living (ADLs) and intention of a second donation in hematopoietic stem cell (HSC) donation. General discomfort and limitations in ADLs were assessed by numerical measurement (scores of 0-10) and donor's intention of a second donation by yes or no reply. The post-donation questionnaires were completed within 48 h after HSC collection and at 1 week, 4 weeks, and 4 months thereafter. Predictors of general discomfort included female sex (P<0.0001), bone marrow (BM) collection (P<0.0001) or PBSC collection through a central line (CL; P=0.0349), 2-day collection (P=0.0150) and negative or undetermined intention of a second donation on day 1 (P<0.0001). Predictors of limitations in ADLs included age group of 30-39 years (P=0.0046), female sex (P<0.0001), BM collection (P<0.0001) or PBSC collection through a CL (P<0.0001) and negative or undetermined intention of a second donation on day 1 (P<0.0001). The only predictor of positive intention of a second donation was male sex (P=0.0007). Age, sex and collection method and period should be considered risk factors when unrelated HSC donation is performed.
Full Text
https://www.nature.com/bmt/journal/v52/n2/full/bmt2016260a.html
DOI
10.1038/bmt.2016.260
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
유철주(Lyu, Chuhl Joo) ORCID logo https://orcid.org/0000-0001-7124-7818
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154644
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