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간세포암의 정위적 체부 방사선 치료에서 적합한 치료 방침 선택에 관한 연구

Other Titles
 Selection of Proper Modality in Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma 
Authors
 최서희  ;  우중렬  ;  성진실 
Citation
 Journal of Liver Cancer (대한간암학회지), Vol.17(1) : 45-53, 2017 
Journal Title
Journal of Liver Cancer(대한간암학회지)
ISSN
 2288-8128 
Issue Date
2017
Keywords
Radiotherapy ; Hepatocellular carcinoma ; Volumetric-Modulated Arc Therapy ; Helical tomotherapy
Abstract
Background/Aims: As the optimal stereotactic body radiation therapy (SBRT) modality for hepatocellular carcinoma (HCC) has not been confirmed, we aimed herein to provide a practical guideline by our retrospective review. Methods: Thirty-nine patients with primary HCC who underwent liver SBRT via 3 modalities (helical tomotherapy [HT]: 22, volumetric modulated arc therapy [VMAT]: 13, Cyberknife: 4) at our institution between July 2014 and July 2015 were included. Modalities were compared with regard to dose conformity index (CI), homogeneity index (HI), clinical results, and patient compliance. Results: VMAT SBRT had favorable conformity (CI: 0.7±0.2), homogeneity (HI: 1.1±0.0), and shortest treatment time (100.2±26.1 seconds). HT SBRT yielded good dosimetric outcomes, especially in conformity (CI: 1.0±0.2). Although the Cyberknife SBRT synchrony system allowed real-time tumor targeting, the treatment time was longest (3,015.0±447.3 seconds), invasive pre-treatment procedures were required, and the HI (1.3±0.0) was lowest. Conclusions: All 3 modalities yielded competent dosimetric planning parameters. VMAT SBRT was most appropriate for tumors with residual lipiodol or patients with poor conditions. HT SBRT is available for multiple or irregular targets. Cyberknife SBRT is recommended for carefully selected patients and tumors indicated for sono-guided fiducial insertion. (J Liver Cancer 2017;17:45-53)
Files in This Item:
T201701030.pdf Download
DOI
10.17998/jlc.17.1.45
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Seong, Jin Sil(성진실) ORCID logo https://orcid.org/0000-0003-1794-5951
Woo, Joong Yeol(우중열)
Choi, Seo Hee(최서희) ORCID logo https://orcid.org/0000-0002-4083-6414
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154634
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