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Preparation of lidocaine-loaded porous Poly (lactic-co-glycolic acid) microparticles using microfluidic flow focusing and phosphate buffer solution porogen

Authors
 Chul Min Kim  ;  Asad Ullah  ;  Chul Ho Chang  ;  Gyu Man Kim 
Citation
 International Journal of Precision Engineering and Manufacturing, Vol.18(4) : 599-604, 2017 
Journal Title
 International Journal of Precision Engineering and Manufacturing 
ISSN
 2234-7593 
Issue Date
2017
Keywords
Porous microparticle ; PLGA ; Lidocaine ; Microfluidic flow-focusing device ; Local anesthesia ; Drug delivery
Abstract
Local anesthesia is widely used in the treatment of postoperative pain. Long time duration and constant release of the local anesthetic is important for pain control. In this study, a preparation method of porous Poly (lactic-co-glycolic acid) (PLGA) microparticles loaded with local anesthetic, lidocaine was studied. Microfluidic flow-focusing device was used to prepare monodispersed microparticles. A phosphate buffer solution (PBS) was used as porogen. The geometry of microparticles was analyzed, and the drug release profile was determined by UV spectroscopy. Test results showed that porous microparticles are beneficial for sustained release of local anesthetic in long time duration over 40 days.
Full Text
https://link.springer.com/article/10.1007/s12541-017-0071-y
DOI
10.1007/s12541-017-0071-y
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Chang, Chul Ho(장철호) ORCID logo https://orcid.org/0000-0001-5647-8298
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154619
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