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Preparation of lidocaine-loaded porous Poly (lactic-co-glycolic acid) microparticles using microfluidic flow focusing and phosphate buffer solution porogen

DC FieldValueLanguage
dc.contributor.author장철호-
dc.date.accessioned2017-11-02T08:34:04Z-
dc.date.available2017-11-02T08:34:04Z-
dc.date.issued2017-
dc.identifier.issn2234-7593-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/154619-
dc.description.abstractLocal anesthesia is widely used in the treatment of postoperative pain. Long time duration and constant release of the local anesthetic is important for pain control. In this study, a preparation method of porous Poly (lactic-co-glycolic acid) (PLGA) microparticles loaded with local anesthetic, lidocaine was studied. Microfluidic flow-focusing device was used to prepare monodispersed microparticles. A phosphate buffer solution (PBS) was used as porogen. The geometry of microparticles was analyzed, and the drug release profile was determined by UV spectroscopy. Test results showed that porous microparticles are beneficial for sustained release of local anesthetic in long time duration over 40 days.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringer-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF PRECISION ENGINEERING AND MANUFACTURING-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titlePreparation of lidocaine-loaded porous Poly (lactic-co-glycolic acid) microparticles using microfluidic flow focusing and phosphate buffer solution porogen-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Anesthesiology and Pain Medicine-
dc.contributor.googleauthorChul Min Kim-
dc.contributor.googleauthorAsad Ullah-
dc.contributor.googleauthorChul Ho Chang-
dc.contributor.googleauthorGyu Man Kim-
dc.identifier.doi10.1007/s12541-017-0071-y-
dc.contributor.localIdA03485-
dc.relation.journalcodeJ01152-
dc.identifier.eissn2005-4602-
dc.identifier.urlhttps://link.springer.com/article/10.1007/s12541-017-0071-y-
dc.subject.keywordPorous microparticle-
dc.subject.keywordPLGA-
dc.subject.keywordLidocaine-
dc.subject.keywordMicrofluidic flow-focusing device-
dc.subject.keywordLocal anesthesia-
dc.subject.keywordDrug delivery-
dc.contributor.alternativeNameChang, Chul Ho-
dc.contributor.affiliatedAuthorChang, Chul Ho-
dc.citation.titleInternational Journal of Precision Engineering and Manufacturing-
dc.citation.volume18-
dc.citation.number4-
dc.citation.startPage599-
dc.citation.endPage604-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF PRECISION ENGINEERING AND MANUFACTURING, Vol.18(4) : 599-604, 2017-
dc.date.modified2017-11-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers

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