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Genetic Predisposition to Sporadic Congenital Hearing Loss in a Pediatric Population

DC FieldValueLanguage
dc.contributor.author윤주헌-
dc.contributor.author정진세-
dc.contributor.author지헌영-
dc.contributor.author최재영-
dc.date.accessioned2017-11-02T08:32:30Z-
dc.date.available2017-11-02T08:32:30Z-
dc.date.issued2017-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/154585-
dc.description.abstractDiscriminating between inherited and non-inherited sporadic hearing loss is challenging. Here, we attempted to delineate genetic inheritance in simplex cases of severe-to-profound congenital hearing loss in Korean children. Variations in SLC26A4 and GJB2 in 28 children with bilateral severe-to-profound non-syndromic hearing loss (NSHL) without familial history were analyzed using Sanger sequencing. Genetic analysis of individuals without mutations in SLC26A4 and GJB2 was performed by whole exome sequencing (WES). Bi-allelic mutations in SLC26A4 and GJB2 were identified in 12 and 3 subjects, respectively. Of the 13 individuals without mutations in SLC26A4 and GJB2, 2 and 1 carried compound heterozygous mutations in MYO15A and CDH23, respectively. Thus, 64.3% (18/28) of individuals with NSHL were determined to be genetically predisposed. Individuals with sporadic severe-to-profound NSHL were found to mostly exhibit an autosomal recessive inheritance pattern. Novel causative candidate genes for NSHL were identified by analysis of WES data of 10 families without mutations in known causative genes. Bi-allelic mutations predisposing to NSHL were identified in 64.3% of subjects with sporadic severe-to-profound NSHL. Given that several causative genes for NSHL are still unidentified, genetic inheritance of sporadic congenital hearing loss could be more common than that indicated by our results.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfSCIENTIFIC REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleGenetic Predisposition to Sporadic Congenital Hearing Loss in a Pediatric Population-
dc.typeArticle-
dc.publisher.locationEngland-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Otorhinolaryngology-
dc.contributor.googleauthorJinsei Jung-
dc.contributor.googleauthorJoon Suk Lee-
dc.contributor.googleauthorKyeong Jee Cho-
dc.contributor.googleauthorSeyoung Yu-
dc.contributor.googleauthorJoo-Heon Yoon-
dc.contributor.googleauthorHeon Yung Gee-
dc.contributor.googleauthorJae Young Choi-
dc.identifier.doi10.1038/srep45973-
dc.contributor.localIdA03742-
dc.contributor.localIdA03971-
dc.contributor.localIdA04173-
dc.contributor.localIdA02604-
dc.relation.journalcodeJ02646-
dc.identifier.eissn2045-2322-
dc.identifier.pmid28383030-
dc.contributor.alternativeNameYoon, Joo Heon-
dc.contributor.alternativeNameJung, Jinsei-
dc.contributor.alternativeNameGee, Heon Yung-
dc.contributor.alternativeNameChoi, Jae Young-
dc.contributor.affiliatedAuthorJung, Jinsei-
dc.contributor.affiliatedAuthorGee, Heon Yung-
dc.contributor.affiliatedAuthorChoi, Jae Young-
dc.contributor.affiliatedAuthorYoon, Joo Heon-
dc.citation.titleScientific Reports-
dc.citation.volume7-
dc.citation.startPage45973-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, Vol.7 : 45973, 2017-
dc.date.modified2017-11-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers

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