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Multi-analyte analysis of cytokines that predict outcomes in patients with hepatocellular carcinoma treated with radiotherapy

Authors
 Hyejung Cha  ;  Eun Jung Lee  ;  Jinsil Seong 
Citation
 WORLD JOURNAL OF GASTROENTEROLOGY, Vol.23(11) : 2077-2085, 2017 
Journal Title
WORLD JOURNAL OF GASTROENTEROLOGY
ISSN
 1007-9327 
Issue Date
2017
MeSH
Adult ; Aged ; Biomarkers, Tumor/blood ; Carcinoma, Hepatocellular/blood ; Carcinoma, Hepatocellular/mortality ; Carcinoma, Hepatocellular/radiotherapy* ; Cytokines/blood* ; Female ; Humans ; Interleukins/blood* ; Liver Neoplasms/blood ; Liver Neoplasms/mortality ; Liver Neoplasms/radiotherapy* ; Male ; Middle Aged ; Prognosis ; Prospective Studies ; Survival Rate ; Treatment Outcome ; Tumor Necrosis Factor-alpha/blood*
Keywords
Cytokine ; Hepatocellular carcinoma ; Interleukin-6 ; Radiotherapy
Abstract
AIM: To analyze cytokine levels and to identify their association with outcome in patients with hepatocellular carcinoma (HCC) treated with radiotherapy (RT). METHODS: Patients with HCC who were treated with RT were eligible for this prospective study. Blood samples were collected before and after RT, and serum cytokine levels including interleukin (IL)-1, IL-6, IL-8, IL-10, IL-12, and tumor necrosis factor-α were analyzed. RESULTS: Between 2008 and 2009, 51 patients were enrolled in this study. Baseline IL-6 level was high in patients with a history of pre-RT treatment. Median survival was 13.9 mo with alpha-fetoprotein (AFP) as a significant factor (P = 0.020). Median failure-free survival (FFS) for infield, outfield-intrahepatic and extrahepatic failures were 23.3, 11.5 and 12.0 mo, respectively. Sex and baseline IL-6 level were associated with infield FFS, and baseline IL-10 level was correlated with outfield-intrahepatic FFS. For extrahepatic FFS, AFP was significant (P = 0.034). Patients with a baseline IL-6 level of ≥ 9.7 pg/mL showed worse infield FFS (P = 0.005), and this significance was observed only in treatment-non-naïve patients (P = 0.022). CONCLUSION: In addition to AFP, cytokines seem useful in predicting infield and outfield-intrahepatic failure. Serum cytokines could be useful biomarkers for predicting RT outcome in HCC.
Files in This Item:
T201700648.pdf Download
DOI
10.3748/wjg.v23.i11.2077
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Seong, Jin Sil(성진실) ORCID logo https://orcid.org/0000-0003-1794-5951
Lee, Eun Jung(이은정)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154556
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