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Fecal calprotectin as a non-invasive biomarker for intestinal involvement of Behçet's disease

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dc.contributor.author천재희-
dc.contributor.author김승원-
dc.contributor.author김원호-
dc.contributor.author김태일-
dc.contributor.author박수정-
dc.contributor.author홍성필-
dc.contributor.author박예현-
dc.date.accessioned2017-11-02T08:29:34Z-
dc.date.available2017-11-02T08:29:34Z-
dc.date.issued2017-
dc.identifier.issn0815-9319-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/154526-
dc.description.abstractBACKGROUND AND AIM: The diagnostic and prognostic values of fecal calprotectin (FC) levels in patients with inflammatory bowel diseases have been proven. However, little is known about the usefulness of FC measurement in predicting intestinal involvement of Behçet's disease (BD). METHODS: Forty-four consecutive patients with systemic BD who underwent colonoscopy for the evaluation of gastrointestinal symptoms were prospectively enrolled between November 2012 and March 2014 in a single tertiary medical center. Fecal specimens from the patients were obtained the day before bowel cleansing and 3 months after colonoscopy. RESULTS: Twenty-five patients showed intestinal ulcerations on colonoscopy (12 [48.0%] typical and 13 [52.0%] atypical ulcerations). The median FC level in the intestinal BD group was significantly higher than that in the non-diagnostic group (112.53 [6.86-1604.39] vs 31.64 [5.46-347.60] µg/g, respectively, P = 0.003). Moreover, the typical ulceration group showed a significantly higher median FC level than the atypical ulceration group in patients with intestinal BD (435.995 [75.65-1604.39] vs 71.42 [6.86-476.94] µg/g, respectively, P = 0.033). Multivariate analysis revealed higher FC as an independent predictor of intestinal BD (OR = 38.776; 95% CI = 2.306-652.021; P = 0.011). The cut-off level of FC for predicting intestinal BD was 68.89 µg/g (76% sensitivity and 79% specificity). The absolute changes between fecal calprotectin levels and the disease activity index of intestinal BD from initial diagnosis of intestinal BD to 3 months after diagnosis were significantly correlated (Pearson's correlation coefficient = 0.470, P = 0.027). CONCLUSION: The FC level might serve as a non-invasive surrogate marker of intestinal involvement of BD.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherBlackwell Scientific Publications-
dc.relation.isPartOfJOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBehcet Syndrome/complications-
dc.subject.MESHBehcet Syndrome/diagnosis*-
dc.subject.MESHBiomarkers/analysis-
dc.subject.MESHFeces/chemistry*-
dc.subject.MESHFemale-
dc.subject.MESHGastrointestinal Diseases/diagnosis*-
dc.subject.MESHGastrointestinal Diseases/etiology-
dc.subject.MESHHumans-
dc.subject.MESHLeukocyte L1 Antigen Complex/analysis*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHPrognosis-
dc.subject.MESHProspective Studies-
dc.subject.MESHUlcer/diagnosis*-
dc.subject.MESHUlcer/etiology-
dc.subject.MESHYoung Adult-
dc.titleFecal calprotectin as a non-invasive biomarker for intestinal involvement of Behçet's disease-
dc.typeArticle-
dc.publisher.locationAustralia-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorDuk Hwan Kim-
dc.contributor.googleauthorYehyun Park-
dc.contributor.googleauthorBun Kim-
dc.contributor.googleauthorSeung Won Kim-
dc.contributor.googleauthorSoo Jung Park-
dc.contributor.googleauthorSung Pil Hong-
dc.contributor.googleauthorTae Il Kim-
dc.contributor.googleauthorWon Ho Kim-
dc.contributor.googleauthorJae Hee Cheon-
dc.identifier.doi10.1111/jgh.13530-
dc.contributor.localIdA00656-
dc.contributor.localIdA00774-
dc.contributor.localIdA01079-
dc.contributor.localIdA01539-
dc.contributor.localIdA04404-
dc.contributor.localIdA04030-
dc.relation.journalcodeJ01417-
dc.identifier.eissn1440-1746-
dc.identifier.pmid27521492-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/jgh.13530/abstract-
dc.subject.keywordcolonoscopy-
dc.subject.keywordfecal calprotectin-
dc.subject.keywordintestinal Behçet's disease-
dc.contributor.alternativeNameCheon, Jae Hee-
dc.contributor.alternativeNameKim, Seung Won-
dc.contributor.alternativeNameKim, Won Ho-
dc.contributor.alternativeNameKim, Tae Il-
dc.contributor.alternativeNamePark, Soo Jung-
dc.contributor.alternativeNameHong, Sung Pil-
dc.contributor.affiliatedAuthorKim, Seung Won-
dc.contributor.affiliatedAuthorKim, Won Ho-
dc.contributor.affiliatedAuthorKim, Tae Il-
dc.contributor.affiliatedAuthorPark, Soo Jung-
dc.contributor.affiliatedAuthorHong, Sung Pil-
dc.contributor.affiliatedAuthorCheon, Jae Hee-
dc.citation.titleJournal of Gastroenterology and Hepatology-
dc.citation.volume32-
dc.citation.number3-
dc.citation.startPage595-
dc.citation.endPage601-
dc.identifier.bibliographicCitationJOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Vol.32(3) : 595-601, 2017-
dc.date.modified2017-11-01-
dc.identifier.rimsid43575-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Others (기타) > 1. Journal Papers

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