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ACTH-producing neuroendocrine tumor of the pancreas: a case report and literature review

Authors
 Justin Byun  ;  Sung Hyun Kim  ;  Hyang Sook Jeong  ;  Yumie Rhee  ;  Woo Jung Lee  ;  Chang Moo Kang 
Citation
 Annals of Hepato-biliary-pancreatic Surgery, Vol.21(1) : 61-65, 2017 
Journal Title
 Annals of Hepato-biliary-pancreatic Surgery 
ISSN
 2508-5778 
Issue Date
2017
Keywords
ACTH ; Neuroendocrine tumor ; Pancreas ; Surgery
Abstract
Tumors that arise from the endocrine pancreas, or the islets of pancreas, are called pancreatic neuroendocrine tumors (NETs). Pancreatic NET have an incidence of <0.1 per one million persons, and can lead to secretion of ectopic adrenocorticotropic hormone (ACTH). Herein, we presented a case of patient with Cushing's syndrome as a result of ACTH-producing pancreatic NET, who underwent successful laparoscopic distal pancreatosplenectomy. A 40-year-old Korean female patient with ophthalmologic discomfort, osteoporosis, and unexplained hypokalemia was admitted to our hospital. Under the suspicion of ACTH producing pancreatic NET after the diagnostic workup, we decided to perform surgical resection. Laparoscopic distal pancreatosplenectomy was performed; and the pathological examination revealed a 1.5 cm-sized grade 2 neuroendocrine tumor of the pancreas, which was encapsulated within the pancreatic parenchyma. After the operation, the patient no longer displayed cushingoid features. ACTH-producing pancreatic NET is rare, but can be one of the causes of Cushing's syndrome. Surgical resection is a feasible option in treating ACTH-producing pancreatic NET.
Files in This Item:
T201700673.pdf Download
DOI
10.14701/ahbps.2017.21.1.61
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Chang Moo(강창무) ORCID logo https://orcid.org/0000-0002-5382-4658
Kim, Sung Hyun(김성현)
Lee, Woo Jung(이우정) ORCID logo https://orcid.org/0000-0001-9273-261X
Rhee, Yumie(이유미) ORCID logo https://orcid.org/0000-0003-4227-5638
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154505
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