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Cutting Edge: Fetal/Placental Type I IFN Can Affect Maternal Survival and Fetal Viral Load during Viral Infection

Authors
 Karen Racicot  ;  Paulomi Aldo  ;  Ayman El-Guindy  ;  Ja-Young Kwon  ;  Roberto Romero  ;  Gil Mor 
Citation
 Journal of Immunology, Vol.198(8) : 3029-3032, 2017 
Journal Title
 Journal of Immunology 
ISSN
 0022-1767 
Issue Date
2017
MeSH
Animals ; Female ; Fetus/immunology* ; Genotype ; Herpesviridae Infections/immunology* ; Interferon Type I/immunology* ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Placenta/immunology* ; Pregnancy ; Pregnancy Complications, Infectious/immunology* ; Rhadinovirus/immunology ; Tumor Virus Infections/immunology ; Viral Load
Abstract
Pregnant women have greater mortality and complications associated with viral infections compared with the general population, but the reason for the increased susceptibility is not well defined. Placenta type I IFN is an important immune modulator and protects the pregnancy. We hypothesized that loss of placental IFN affects the regulation of the maternal immune system, resulting in the differential response to infections observed in pregnancy. Pregnant mice lacking the IFN-α/β receptor (IFNAR) became viremic and had higher mortality compared with nonpregnant animals. Notably, an embryo with functional IFN signaling alone was sufficient to rescue the pregnant IFNAR-/- dam from virus-associated demise. Placental IFN was also an important regulator of viral replication in placental tissue and significantly affected viral transmission to the fetus. These findings highlight the role of fetal/placental IFN in the modulation of viral infection in the mother and fetus.
Full Text
http://www.jimmunol.org/content/198/8/3029.long
DOI
10.4049/jimmunol.1601824
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
권자영(Kwon, Ja Young) ORCID logo https://orcid.org/0000-0003-3009-6325
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154493
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