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Evaluation of Drug Sorption to PVC- and Non-PVC-based Tubes in Administration Sets Using a Pump

 Su-Eon Jin  ;  Siwon You  ;  Seungho Jeon  ;  Hyo-Jin Byon  ;  Sung-Joo Hwang 
 Journal of Visualized Experiments : JoVE, Vol.121 : 55086, 2017 
Journal Title
 Journal of Visualized Experiments : JoVE 
Issue Date
Adsorption ; Chromatography, High Pressure Liquid ; Diazepam/analysis ; Diazepam/chemistry ; Drug Administration Routes ; Equipment Design ; Pharmaceutical Preparations/analysis ; Pharmaceutical Preparations/chemistry* ; Polyvinyl Chloride/chemistry* ; Tacrolimus/analysis ; Tacrolimus/chemistry
Administration sets are delivery tools for the direct application of drugs into the body and are composed of a spike, a drip chamber, tubes, Luer adapters (connectors), a needle cover for protection, and other accessories. Drug sorption to tubes of administration sets is a critical issue in terms of safety and efficacy. Although drug sorption is an important factor in the quality of an administration set, there are no standard evaluation methods for the regulation of drug sorption to the tubes. Here, we describe an evaluation protocol for drug sorption to tubes of administration sets. Tubes made of polyvinyl chloride (PVC)- and non-PVC-based polymeric materials were cut to 1 m in length. Diazepam and tacrolimus were used as model drugs. In the kinetic sorption study, we selected the drug concentration and flow rate based on the clinical usage of these drugs. After the dilution of each drug in a glass bottle, the diluted drug solution was delivered through tubes of administration sets using a pump. Samples were collected in amber vials at appropriate time points and the drugs were analyzed using high-performance liquid chromatography. Drug concentrations and sorption levels to tubes of the administration sets were calculated. Acceptable criteria to ensure the quality of administration sets are recommended.
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1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Byon, Hyo Jin(변효진)
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