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Gastroesophageal Reflux in Neurologically Impaired Children: What Are the Risk Factors?

Authors
 Seung Kim  ;  Hong Koh  ;  Joon Soo Lee 
Citation
 Gut and Liver, Vol.11(2) : 232-236, 2017 
Journal Title
 Gut and Liver 
ISSN
 1976-2283 
Issue Date
2017
MeSH
Central Nervous System Diseases/complications* ; Central Nervous System Diseases/diagnostic imaging ; Cerebral Palsy/complications ; Child, Preschool ; Electroencephalography ; Epilepsy/complications ; Esophageal pH Monitoring ; Female ; Gastroesophageal Reflux/diagnosis ; Gastroesophageal Reflux/etiology* ; Humans ; Infant ; Male ; Mitochondrial Diseases/complications ; Risk Factors
Keywords
Child ; Esophageal pH monitoring ; Gastroesophageal reflux
Abstract
BACKGROUND/AIMS: Neurologically impaired patients frequently suffer from gastrointestinal tract problems, such as gastroesophageal reflux disease (GERD). In this study, we aimed to define the risk factors for GERD in neurologically impaired children. METHODS: From May 2006 to March 2014, 101 neurologically impaired children who received 24-hour esophageal pH monitoring at Severance Children's Hospital were enrolled in the study. The esophageal pH finding and the clinical characteristics of the patients were analyzed. RESULTS: The reflux index was higher in patients with abnormal electroencephalography (EEG) results than in those with normal EEG results (p=0.027). Mitochondrial disease was associated with a higher reflux index than were epileptic disorders or cerebral palsy (p=0.009). Patient gender, feeding method, scoliosis, tracheostomy, and baclofen use did not lead to statistical differences in reflux index. Age of onset of neurological impairment was inversely correlated with DeMeester score and reflux index. Age at the time of examination, the duration of the disease, and the number of antiepileptic drugs were not correlated with GER severity. CONCLUSIONS : Early-onset neurological impairment, abnormal EEG results, and mitochondrial disease are risk factors for severe GERD.
Files in This Item:
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DOI
10.5009/gnl16150.
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
고홍(Koh, Hong) ORCID logo https://orcid.org/0000-0002-3660-7483
김승(Kim, Seung) ORCID logo https://orcid.org/0000-0003-4373-9828
이준수(Lee, Joon Soo) ORCID logo https://orcid.org/0000-0001-9036-9343
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154487
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