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Autonomic response during bladder hydrodistention reflects the severity of symptoms in patients with bladder pain syndrome/interstitial cystitis

Authors
 Sang Woon Kim  ;  Hee Seo Son  ;  Irela Soto Troya  ;  Ji Yu Kim  ;  Myoung Joo Kim  ;  Matthew O. Fraser  ;  Jang Hwan Kim 
Citation
 Neurourology and Urodynamics, Vol.36(3) : 677-682, 2017 
Journal Title
 Neurourology and Urodynamics 
ISSN
 0733-2467 
Issue Date
2017
MeSH
Adult ; Aged ; Autonomic Nervous System/physiopathology* ; Blood Pressure/physiology* ; Cystitis, Interstitial/diagnosis* ; Cystitis, Interstitial/physiopathology ; Databases, Factual ; Female ; Heart Rate/physiology* ; Humans ; Male ; Middle Aged ; Pain/diagnosis* ; Pain/physiopathology ; Retrospective Studies ; Severity of Illness Index ; Urinary Bladder/physiopathology*
Keywords
autonomic nervous system ; bladder pain syndrome ; interstitial cystitis
Abstract
AIMS: To evaluate the correlation between symptom severity of bladder pain syndrome/interstitial cystitis (BPS/IC) and autonomic nervous system activity, we examined autonomic responses during bladder hydrodistention. METHODS: Medical records were collected from a prospective database for patients who underwent bladder hydrodistention with a fixed protocol from March 2012 to December 2013. A total of 40 patients (16 males, 24 females) were included for the analysis. Hydrodistention was performed under general anesthesia (31 patients), spinal anesthesia (six patients), and both types of anesthesia (three patients) at different times. Twenty-five patients who underwent holmium laser enucleation of the prostate served as controls. Pulse rate (PR), systolic (SBP), and diastolic blood pressure (BP) were measured pre-hydrodistention, during hydrodistention, and after drainage. RESULTS: The spinal anesthesia and control groups exhibited little change in BP and PR during hydrodistention, while a significant increase was demonstrated in the general anesthesia group (e.g., ΔSBP 4.89 ± 4.80, 10.40 ± 19.03, and 56.26 ± 30.38 mm Hg, respectively, P < 0.001). Under general anesthesia, autonomic response during hydrodistention was more prominent in patients with preoperative visual analogue scale (VAS) pain score ≥7, Hunner's lesion, and glomerulation grade 4. Preoperative maximal cystometric capacity negatively correlated with changes in SBP during hydrodistention (R2  = 0.294, P = 0.009), while VAS score and interstitial cystitis problem index demonstrated a positive correlation with the changes (R2  = 0.208, P = 0.012; R2  = 0.173, P = 0.015). CONCLUSIONS: Under general anesthesia, exaggerated autonomic responses to bladder hydrodistention were demonstrated in BPS/IC patients, which reflected the severity of symptoms. These results support the hypothesis of altered activity of autonomic system in BPS/IC. Neurourol. Urodynam. 36:677-682, 2017. © 2016 Wiley Periodicals, Inc.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/nau.22994/abstract
DOI
10.1002/nau.22994
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
김명수(Kim, Myung Soo)
김상운(Kim, Sang Woon) ORCID logo https://orcid.org/0000-0002-5790-1948
김장환(Kim, Jang Hwan)
손희서(Son, Hee Seo) ORCID logo https://orcid.org/0000-0001-7198-7816
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154486
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