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Harvesting of Living Cell Sheets by the Dynamic Generation of Diffractive Photothermal Pattern on PEDOT

Authors
 Jongbeom Na  ;  June Seok Heo  ;  Minsu Han  ;  Hanwhuy Lim  ;  Hyun Ok Kim  ;  Eunkyoung Kim 
Citation
 Advanced Functional Materials, Vol.27(10) : 1604260-1604260, 2017 
Journal Title
 Advanced Functional Materials 
ISSN
 1616-301X 
Issue Date
2017
Abstract
Near infrared (NIR) photothermal pattern on conductive polymer film enables unique approaches to harvest large-area cell sheets with various patterns without the use of patterned culture dish. The NIR photothermal pattern is generated from a patterned optical lens (POL), which creates a dynamic near IR light pattern and the corresponding photothermal pattern (PTP) on the polymer film. The POL is prepared from transparent polydimethylsiloxane designed to generate various light patterns. The PTPs allow a noninvasive harvest of cultured cells as an intact living cell sheet with a high harvesting efficiency (ηcell > 100). Various PTPs are generated by the diffraction of NIR light through POLs having different micropatterns, which afford cell sheets with a desired pattern without changing the original cell morphology at cultured state. Furthermore, a large-area living cell sheet is obtained with a detached area larger than 19 cm2, which is the largest living cell sheet up to date. Further optical engineering of the harvesting system allows multiple productions of cell sheets with one dose of light. It is possible to harvest cell sheets not only from human fibroblast cells but also from human adipose-derived stem cells, indicating that the method can be applied to engineer various cells.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/adfm.201604260/abstract
DOI
10.1002/adfm.201604260
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
김현옥(Kim, Hyun Ok) ORCID logo https://orcid.org/0000-0002-4964-1963
허준석(Heo, June Seok)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154485
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