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Epidemiology and Clinical Features of Kawasaki Disease in South Korea, 2012-2014

 Gi Beom Kim  ;  Sohee Park  ;  Lucy Youngmin Eun  ;  Ji Whan Han  ;  Soo Young Lee  ;  Kyung Lim Yoon  ;  Jeong Jin Yu  ;  Jong-Woon Choi  ;  Kyung-Yil Lee 
 Pediatric Infectious Disease Journal, Vol.36(5) : 482-485, 2017 
Journal Title
 Pediatric Infectious Disease Journal 
Issue Date
Adolescent ; Age Distribution ; Child ; Child, Preschool ; Coronary Aneurysm/epidemiology ; Coronary Aneurysm/etiology ; Female ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Incidence ; Infant ; Male ; Mucocutaneous Lymph Node Syndrome/complications ; Mucocutaneous Lymph Node Syndrome/epidemiology* ; Mucocutaneous Lymph Node Syndrome/pathology* ; Republic of Korea/epidemiology ; Seasons ; Sex Distribution ; Surveys and Questionnaires ; Young Adult
Kawasaki disease ; epidemiology ; incidence ; mucocutaneous lymph node syndrome
BACKGROUND: To reveal the recent epidemiologic features of Kawasaki disease (KD) in South Korea based on data from a nationwide survey. METHODS: We collected data between 2012 and 2014 regarding the incidence, symptoms and signs, treatment trends and coronary complications associated with acute KD by sending questionnaires to 97 hospitals with pediatric residency programs as well as 19 community hospitals without residency training. RESULTS: We received full and partial data from 97 and 13 hospitals, respectively (response rate: 94.8%). A total of 14,916 cases of KD were reported by these 110 hospitals (4588 in 2012, 5183 in 2013 and 5145 in 2014). The male-to-female ratio was 1.4:1, and the median age at diagnosis was 29 months. The incidence of KD per 100,000 children younger than 5 years of age were 170.9, 194.9 and 194.7 in 2012, 2013 and 2014, respectively. The recurrence rate was 4.7%. KD occurred more frequently during summer (especially June and July) and winter (December and January) seasons. Intravenous immunoglobulin was administered to 95.4% of the patients, and the nonresponder rate for the first intravenous immunoglobulin was 11.8%. Coronary aneurysm occurred in 1.7% of the patients, and giant aneurysm developed in 19 patients (0.16%) during the 3 years. One patient had myocardial infarction and 1 patient died of suspected coronary aneurysm rupture. CONCLUSIONS: The incidence of KD in South Korea increased to 194.7 per 100,000 children younger than 5 years in 2014; meanwhile, the coronary aneurysm rate decreased to 1.7%.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Eun, Lucy Youngmin(은영민) ORCID logo https://orcid.org/0000-0002-4577-3168
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