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First report of blaOXA-499 as a carbapenemase 1 gene from Acinetobacter pittii
- Authors
- Roshan D'Souza ; Naina Adren Pinto ; Paul G. Higgins ; Insik Hwang ; Dongeun Yong ; Jongrak Choi ; Kyoungwon Lee ; Yunsop Chong
- Citation
- ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Vol.61(5) : e02676-16, 2017
- Journal Title
- ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- ISSN
- 0066-4804
- Issue Date
- 2017
- MeSH
- Acinetobacter/drug effects ; Acinetobacter/genetics* ; Acinetobacter/isolation & purification ; Acinetobacter Infections/drug therapy* ; Acinetobacter Infections/microbiology ; Aged ; Anti-Bacterial Agents/pharmacology* ; Bacterial Proteins/genetics* ; Carbapenems/pharmacology* ; DNA, Bacterial/genetics ; Humans ; Male ; Microbial Sensitivity Tests ; Sequence Analysis, DNA ; beta-Lactam Resistance/genetics* ; beta-Lactamases/genetics*
- Keywords
- Acinetobacter pittii ; OXA-143-like ; OXA-499 ; carbapenemase resistant
- Abstract
- We identified the carbapenemase gene blaOXA-499, a variant of blaOXA-143, from a clinical isolate of Acinetobacter pittii for the first time. OXA-499 shared 93.1% amino acid identity with OXA-143, and the gene was located on the chromosome. By cloning the OXA-499-encoding gene into the pWH1266 vector and transforming it into susceptible Acinetobacter spp., we were able to show that OXA-499 confers resistance to carbapenems.
- Appears in Collections:
- 1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
- Yonsei Authors
-
Yong, Dong Eun(용동은)
https://orcid.org/0000-0002-1225-8477
Lee, Kyungwon(이경원) https://orcid.org/0000-0003-3788-2134
Choi, Jong Rak(최종락) https://orcid.org/0000-0002-0608-2989
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