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First report of blaOXA-499 as a carbapenemase 1 gene from Acinetobacter pittii

Authors
 Roshan D'Souza  ;  Naina Adren Pinto  ;  Paul G. Higgins  ;  Insik Hwang  ;  Dongeun Yong  ;  Jongrak Choi  ;  Kyoungwon Lee  ;  Yunsop Chong 
Citation
 ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Vol.61(5) : e02676-16, 2017 
Journal Title
 ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 
ISSN
 0066-4804 
Issue Date
2017
MeSH
Acinetobacter/drug effects ; Acinetobacter/genetics* ; Acinetobacter/isolation & purification ; Acinetobacter Infections/drug therapy* ; Acinetobacter Infections/microbiology ; Aged ; Anti-Bacterial Agents/pharmacology* ; Bacterial Proteins/genetics* ; Carbapenems/pharmacology* ; DNA, Bacterial/genetics ; Humans ; Male ; Microbial Sensitivity Tests ; Sequence Analysis, DNA ; beta-Lactam Resistance/genetics* ; beta-Lactamases/genetics*
Keywords
Acinetobacter pittii ; OXA-143-like ; OXA-499 ; carbapenemase resistant
Abstract
We identified the carbapenemase gene blaOXA-499, a variant of blaOXA-143, from a clinical isolate of Acinetobacter pittii for the first time. OXA-499 shared 93.1% amino acid identity with OXA-143, and the gene was located on the chromosome. By cloning the OXA-499-encoding gene into the pWH1266 vector and transforming it into susceptible Acinetobacter spp., we were able to show that OXA-499 confers resistance to carbapenems.
Full Text
http://aac.asm.org/content/61/5/e02676-16.long
DOI
10.1128/AAC.02676-16
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
Choi, Jong Rak(최종락) ORCID logo https://orcid.org/0000-0002-0608-2989
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154363
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